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2'-5'-oligoadenylate synthetase activity

Known as: (2-5')oligo(A) synthetase activity, 2'-5' oligoadenylate synthetase activity, 2-5A synthetase activity 
Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. This reaction requires the binding of double-stranded RNA. [ISBN:0198506732]
National Institutes of Health

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2-5A Synthetase

Papers overview

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2019
2019
Transcriptome sequencing in a 6-hydroxydopamine rat model of Parkinson's disease.
The neurotoxin 6-hydroxydopamine (6-OHDA) has been widely exploited as a tool for modeling Parkinson's disease (PD) in the rat… 
Highly Cited
2008
Highly Cited
2008
The p59 oligoadenylate synthetase-like protein possesses antiviral activity that requires the C-terminal ubiquitin-like domain.
Viral infection of mammalian cells prompts the innate immune system to initiate an antiviral response. The recognition of the… 
2004
2004
Interaction between the 2'-5' oligoadenylate synthetase-like protein p59 OASL and the transcriptional repressor methyl CpG-binding protein 1.
The human 2'-5' oligoadenylate synthetases (OAS) form a conserved family of interferon-induced proteins consisting of four genes… 
1996
1996
Involvement of interleukin-6 and interferon-alpha in the poly(A).Poly(U)-induced 2',5'-oligoadenylate synthetase activity in the mouse monocyte-macrophage cell line, J774A1.
The synthetic polyribonucleotide poly(A).poly(U) induces 2',5'-oligoadenylate synthetase activity in the murine macrophage cell… 
Highly Cited
1993
Highly Cited
1993
Inhibition of interferon-gamma-induced major histocompatibility complex class II gene transcription by interferon-beta and type beta 1 transforming growth factor in human astrocytoma cells…
1991
1991
[2'-5' oligoadenylate synthetase activity in patients with acute viral hepatitis and chronic type B hepatitis, and its clinical significance].
The levels of 2'-5' oligoadenylate synthetase activity (2-5AS) were measured in the lymphocytes and sera of 32 patients with… 
1989
1989
2'-5' oligo-A-synthetase activity in bovine peripheral blood leukocytes and alveolar macrophages exposed to recombinant interferons and tumor necrosis factor-alpha.
In vitro treatment of bovine peripheral blood mononuclear leukocytes, polymorphonuclear neutrophilic granulocytes and alveolar… 
1988
1988
Interferon gamma is active on human lymphoblastoid Namalva cells without inducing an antiviral state.
1987
1987
Effect of mouse interferon alpha/beta on the expression of H-2 (class I) antigens and on the levels of 2'-5' oligoadenylate synthetase activity in interferon-sensitive and interferon-resistant Friend…
DBA/2 mice were injected intraperitoneally (i.p.) with interferon-sensitive 745 or interferon-resistant 3C1-8 Friend… 
1984
1984
Oligo-2',5'-adenylate synthetase activity in peripheral blood mononuclear leukocytes in various diseases
Interferon induces oligo-2',5'-adenylate synthetase in cells. In various diseases, interferon was detectable in the circulation… 
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