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2-5A Synthetase

Known as: Synthetase, 2,5 Oligoadenylate, 2,5 Oligoadenylate Polymerase, Oligoadenylate Polymerase, 2,5 
An enzyme that catalyzes the conversion of ATP into a series of (2'-5') linked oligoadenylates and pyrophosphate in the presence of double-stranded… 
National Institutes of Health

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2'-5'-oligoadenylate synthetase activityIn BloodProcess of secretionantagonists & inhibitors

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Papers overview

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Highly Cited
2005
Highly Cited
2005
Hepatitis C virus core protein down-regulates transcription of interferon-induced antiviral genes.
BACKGROUND Hepatitis C virus (HCV) proteins interfere with the interferon (IFN)-alpha-induced Jak/signal transducer and activator… 
Highly Cited
2000
Highly Cited
2000
Activation of the Interferon-Inducible 2′-5′-Oligoadenylate Synthetase Gene by Hepatitis C Virus Core Protein
ABSTRACT The effects of hepatitis C virus (HCV) proteins on several signal transduction pathways in human nonneoplastic… 
Highly Cited
1998
Highly Cited
1998
Poor induction of interferon-induced 2′,5′-oligoadenylate synthetase (2–5 AS) in cells persistently infected with mumps virus is caused by decrease of STAT-1α
SummaryPoor induction of interferon-induced 2′,5′-oligoadenylate synthetase (2-5AS) has been demonstrated in cells persistently… 
Highly Cited
1994
Highly Cited
1994
Upregulation of the 2-5A synthetase/RNase L antiviral pathway associated with chronic fatigue syndrome.
Levels of 2',5'-oligoadenylate (2-5A) synthetase, bioactive 2-5A, and RNase L were measured in extracts of peripheral blood… 
Highly Cited
1994
Highly Cited
1994
Changes in the 2-5A synthetase/RNase L antiviral pathway in a controlled clinical trial with poly(I)-poly(C12U) in chronic fatigue syndrome.
Latent 2', 5'-oligoadenylate (2-5A) synthetase activity, bioactive 2-5A and RNase L activity were measured in extracts of… 
Highly Cited
1990
Highly Cited
1990
Regulation of carcinoembryonic antigen expression in different human colorectal tumor cells by interferon-gamma.
The regulation of carcinoembryonic antigen (CEA) expression by recombinant human interferon-gamma (IFN-gamma) was studied in a… 
Highly Cited
1990
Highly Cited
1990
A selective defect of interferon alpha production in human immunodeficiency virus-infected monocytes [published erratum appears in J Exp Med 1991 Jan 1;173(1):277]
Interferon alpha (IFN-alpha) induces significant antiretroviral activities that affect the ability of human immunodeficiency… 
1988
1988
Effect of endogenous and exogenous interferons on the differentiation of human monocyte cell line U937.
The effect of interferons (IFNs) on the differentiation of hematopoietic cells was examined with the human monocyte cell line… 
Highly Cited
1985
Highly Cited
1985
Continuous production of interferon in normal mice: effect of anti-interferon globulin, sex, age, strain and environment on the levels of 2-5A synthetase and p67K kinase.
Two interferon-mediated enzymes, a 2-5A synthetase and a kinase that phosphorylates a 67 000 mol. wt. (p67K) protein were found… 
Highly Cited
1979
Highly Cited
1979
2',5'-Oligoadenylate synthetase activity in lymphocytes from normal mouse.
The activity of 2',5'-oligoadenylate synthetase, an enzyme recently discovered in interferon-treated cells, was found in… 
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