2-5A Synthetase

Known as: Synthetase, 2,5 Oligoadenylate, 2,5 Oligoadenylate Polymerase, Oligoadenylate Polymerase, 2,5 
An enzyme that catalyzes the conversion of ATP into a series of (2'-5') linked oligoadenylates and pyrophosphate in the presence of double-stranded… (More)
National Institutes of Health

Papers overview

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Review
2007
Review
2007
The demonstration by Kerr and colleagues that double-stranded (ds) RNA inhibits drastically protein synthesis in cell-free… (More)
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Highly Cited
2007
Highly Cited
2007
Antiviral innate immunity is initiated in response to RNA molecules that are produced in virus-infected cells. These RNAs… (More)
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Highly Cited
2006
Highly Cited
2006
Interleukin-28A (IL-28A), IL-28B and IL-29 are a family of class II cytokines that stimulate antiviral responses through a… (More)
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Highly Cited
2005
Highly Cited
2005
The objective of this study was to examine the expression of TLR by human primary uterine epithelial cells (UEC) and to determine… (More)
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Review
1999
Review
1999
2',5'-Oligoadenylate synthetase (2',5'-OAS) was discovered and characterized as an interferon (IFN)-induced enzyme that in the… (More)
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1999
1999
The Interferon Regulatory Factors-1 and -2 (IRF-1 and IRF-2) were originally identified as transcriptional regulators of the… (More)
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Highly Cited
1998
Highly Cited
1998
Induction of apoptosis in mammalian cells by double-stranded (ds) RNA-dependent enzymes, protein kinase (PKR), and 2-5A… (More)
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Review
1998
Review
1998
The 2-5A system is an established endogenous antiviral pathway. Interferon treatment of cells leads to an increase in basal, but… (More)
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1994
1994
Levels of 2',5'-oligoadenylate (2-5A) synthetase, bioactive 2-5A, and RNase L were measured in extracts of peripheral blood… (More)
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1990
1990
Treatment of cells with interferons (IFNs) induces resistance to virus infection. The 2'-5'oligo A (2-5A) synthetase/RNase L is… (More)
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