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Assessing the root of bilaterian animals with scalable phylogenomic methods
  • A. Hejnol, M. Obst, +14 authors C. Dunn
  • Biology, Medicine
  • Proceedings of the Royal Society B: Biological…
  • 22 December 2009
New sequence data and methods strongly uphold previous suggestions that Acoelomorpha is sister clade to all other bilaterian animals, find diminishing evidence for the placement of the enigmatic Xenoturbella within Deuterostomia, and place Cycliophora with Entoprocta and EctoproCTa. Expand
Deep metazoan phylogeny: when different genes tell different stories.
The accuracy of phylogenetic inference may be substantially improved by selecting genes that evolve slowly across the Metazoa and applying more realistic substitution models, as well as modifying gene sampling and the taxonomic composition of the outgroup. Expand
Primmorphs generated from dissociated cells of the sponge Suberites domuncula: a model system for studies of cell proliferation and cell death
It is proposed that the primmorph system described here is a powerful novel model system to study basic mechanisms of cell proliferation and cell interaction, as well as of morphogenesis, ageing and apoptosis. Expand
Cytotoxic metabolites from the fungal endophyte Alternaria sp. and their subsequent detection in its host plant Polygonum senegalense.
From the Egyptian medicinal plant Polygonum senegalense the fungal endophyte Alternaria sp. was isolated. Extracts of the fungus grown either in liquid culture or on solid rice media exhibitedExpand
Establishment of a primary cell culture from a sponge: primmorphs from Suberites domuncula
It is proposed that the primmorph system described here is a powerful novel model system to study basic mechanisms of cell proliferation and cell death; it can also be used in aquaculture, for the production of bioactive compounds and as a bioindicator system. Expand
Innate Immune Defense of the Sponge Suberites domuncula against Bacteria Involves a MyD88-dependent Signaling Pathway
Data indicate that S. domuncula is provided with an innate immune system against Gram-negative bacteria; the ligand LPS (a pathogen-associated molecular pattern) is recognized by the pattern recognition receptor (LPS-interacting protein), which interacts with MyD88. Expand
Review: How was metazoan threshold crossed? The hypothetical Urmetazoa.
  • W. Müller
  • Biology, Medicine
  • Comparative biochemistry and physiology. Part A…
  • 1 June 2001
It is concluded that molecular biological studies with sponges as models will not only help to understand the evolution of metazoan evolution but also the complex, hierarchical regulatory network of cells in higher Metazoa. Expand
Formation of siliceous spicules in the marine demosponge Suberites domuncula
Immunohistological analysis has shown that silicatein exists in the axial canal (axial filament) and on the surface of the spicules, suggesting that they grow by apposition, and it is demonstrated that the enzymic reaction of silicatesin is inhibited by anti-silicatein antibodies. Expand
Expression of silicatein and collagen genes in the marine sponge Suberites domuncula is controlled by silicate and myotrophin.
It was found that after increasing the concentration of soluble silicate in the seawater medium from around 1 microM to approximately 60 microM, this gene is strongly upregulated and the expression of collagen is also upregulated in those primmorphs which were treated with recombinant myotrophin obtained from the same sponge. Expand
Toll-like receptors are part of the innate immune defense system of sponges (demospongiae: Porifera).
The identification, cloning, and deduced protein sequence from 3 major elements of the poriferan innate response (to bacterial lipopeptides): the TLR, the IL-1 receptor-associated kinase-4-like protein (IRAK-4l), and a novel effector caspase from the demosponge Suberites domuncula show significant sequence similarity with its homologues in higher Metazoa. Expand