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2'-cyano-2'-deoxyarabinofuranosylcytosine
Known as:
2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine
, 2'-cyano-2'deoxy-1-beta-D-arabinofuranosylcytosine
, CNDAC
National Institutes of Health
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Related topics
Related topics
3 relations
Broader (1)
Cytarabine
Narrower (1)
Nucleoside Analog DFP-10917
analogs & derivatives
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Targeting BRCA1/2 deficient ovarian cancer with CNDAC-based drug combinations
Xiaojun Liu
,
Ying-jun Jiang
,
+4 authors
W. Plunkett
Cancer Chemotherapy and Pharmacology
2018
Corpus ID: 1008487
PurposeThe mechanism of action of CNDAC (2′-C-cyano-2′-deoxy-1-β-d-arabino-pentofuranosyl-cytosine) is unique among deoxycytidine…
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2018
2018
Analysis of the prolonged infusion of DFP-10917, a deoxycytidine analog, as a therapeutic strategy for the treatment of human tumor xenografts in vivo.
Kenzo Iizuka
,
Chun Zhang
,
K. Eshima
,
Cheng Jin
,
K. Eshima
,
M. Fukushima
International Journal of Oncology
2018
Corpus ID: 20997162
2'-C-cyano-2'-deoxy-1-β-D-arabino-pentofranocyl-cytosine (DFP-10917, CNDAC) is a 2'-deoxycytidine analog with antitumor activity…
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2017
2017
Results of a Phase 3 Study of Elderly Patients with Newly Diagnosed AML Treated with Sapacitabine and Decitabine Administered in Alternating Cycles
H. Kantarjian
,
K. Begna
,
+29 authors
J. Chiao
2017
Corpus ID: 220332657
Background: Sapacitabine is a novel oral nucleoside analogue with a unique ability to induce single-strand DNA breaks after…
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2012
2012
Bone Marrow and Peripheral Blood AML Cells Are Highly Sensitive to CNDAC, the Active Form of Sapacitabine
S. Jagan
,
L. Paganessi
,
Robin R. Frank
,
P. Venugopal
,
M. Larson
,
K. Christopherson
Advances in Hematology
2012
Corpus ID: 4058621
Achieving improvements in survival and reducing relapse remains a challenge in acute myelogenous leukemia (AML) patients. This…
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2006
2006
A phase I clinical and pharmacokinetic study of CS-682 administered orally in advanced malignant solid tumors
T. Delaunoit
,
P. Burch
,
+6 authors
C. Erlichman
Investigational new drugs
2006
Corpus ID: 13415855
SummaryCS-682 (1-(2-C-cyano-2-deoxy-β-D-arabino-pentofuranosyl)-N4-palmitoylcytosine) is a novel orally administered 2…
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2005
2005
Molecular basis for G2 arrest induced by 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine and consequences of checkpoint abrogation.
Xiaojun Liu
,
Ying Guo
,
+7 authors
W. Plunkett
Cancer Research
2005
Corpus ID: 12373385
2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine (CNDAC) is a nucleoside analogue with a novel mechanism of action…
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Highly Cited
2004
Highly Cited
2004
Anti‐neovascular therapy by liposomal drug targeted to membrane type‐1 matrix metalloproteinase
Masami Kondo
,
T. Asai
,
+6 authors
N. Oku
International Journal of Cancer
2004
Corpus ID: 25897802
Because membrane type‐1 matrix metalloproteinase (MT1‐MMP) is expressed specifically on the angiogenic endothelium as well as…
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2001
2001
Targeting and anti-tumor efficacy of liposomal 5'-O-dipalmitoylphosphatidyl 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine in mice lung bearing B16BL6 melanoma.
T. Asai
,
S. Shuto
,
+4 authors
N. Oku
Cancer Letters
2001
Corpus ID: 19441538
1999
1999
Determinants in chemosensitivity of oncogene-transformed NIH3T3 cells to 2'-C-cyano-2'-deoxy-1-beta-D-arabinofuranosylcytosine.
M. Zhang
,
Y. Endo
,
T. Sasaki
International Journal of Oncology
1999
Corpus ID: 23884994
2'-C-Cyano-2'-deoxy-1-beta-D-arabinofuranosylcytosine (CNDAC) is a novel 2'-deoxycytidine (dCyd) analogue with potent antitumor…
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1998
1998
Antitumor activity of 5'-O-dipalmitoylphosphatidyl 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine is enhanced by long-circulating liposomalization.
T. Asai
,
K. Kurohane
,
+6 authors
N. Oku
Biological and Pharmaceutical Bulletin
1998
Corpus ID: 1336779
We previously synthesized the 5'-O-diacylphosphatidyl derivative of 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine…
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