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2'-5'-oligoadenylate synthetase activity

Known as: (2-5')oligo(A) synthetase activity, 2'-5' oligoadenylate synthetase activity, 2-5A synthetase activity 
Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. This reaction requires the binding of double-stranded RNA. [ISBN:0198506732]
National Institutes of Health

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2-5A Synthetase

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1997
1997
A Type I Interferon Signaling Factor, ISF21, Encoded on Chromosome 21 Is Distinct from Receptor Components and Their Down-regulation and Is Necessary for Transcriptional Activation of Interferon…
The type I interferons (IFNs) are a family of cytokines, comprising at least 17 subtypes, which exert pleiotropic actions by… 
1996
1996
Involvement of interleukin-6 and interferon-alpha in the poly(A).Poly(U)-induced 2',5'-oligoadenylate synthetase activity in the mouse monocyte-macrophage cell line, J774A1.
The synthetic polyribonucleotide poly(A).poly(U) induces 2',5'-oligoadenylate synthetase activity in the murine macrophage cell… 
1991
1991
[2'-5' oligoadenylate synthetase activity in patients with acute viral hepatitis and chronic type B hepatitis, and its clinical significance].
The levels of 2'-5' oligoadenylate synthetase activity (2-5AS) were measured in the lymphocytes and sera of 32 patients with… 
1989
1989
2'-5' oligo-A-synthetase activity in bovine peripheral blood leukocytes and alveolar macrophages exposed to recombinant interferons and tumor necrosis factor-alpha.
In vitro treatment of bovine peripheral blood mononuclear leukocytes, polymorphonuclear neutrophilic granulocytes and alveolar… 
1988
1988
Interferon gamma is active on human lymphoblastoid Namalva cells without inducing an antiviral state.
1988
1988
Decrease of oligo-2',5'-adenylate synthetase activity in BALB3T3 cell persistently infected with Moloney murine leukemia virus.
1987
1987
Effect of mouse interferon alpha/beta on the expression of H-2 (class I) antigens and on the levels of 2'-5' oligoadenylate synthetase activity in interferon-sensitive and interferon-resistant Friend…
DBA/2 mice were injected intraperitoneally (i.p.) with interferon-sensitive 745 or interferon-resistant 3C1-8 Friend… 
1987
1987
Increased activity of oligo-2',5'-adenylate synthetase in Down's syndrome and epilepsy.
The level of oligo-2',5'-adenylate synthetase activity is a good marker for the response of cells to interferon. This enzyme can… 
1986
1986
Qualitative differences in effects of recombinant alpha-, beta- and gamma-interferons on human peripheral blood leukocytes in vitro.
The in vitro effects of bacteria-produced human interferons alpha 2, beta and gamma on several properties of peripheral blood… 
1984
1984
Oligo-2',5'-adenylate synthetase activity in peripheral blood mononuclear leukocytes in various diseases
Interferon induces oligo-2',5'-adenylate synthetase in cells. In various diseases, interferon was detectable in the circulation… 
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