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Biological Activity of Soluble CD100. II. Soluble CD100, Similarly to H-SemaIII, Inhibits Immune Cell Migration1 2
CD100 is a human 150-kDa homodimer expressed at the surface of most hemopoietic cells, and its gene belongs to the Ig and semaphorin gene families. Semaphorin genes encode soluble and membrane-bound…
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Involvement of BAFF and APRIL in the resistance to apoptosis of B-CLL through an autocrine pathway.
TLDR
Results indicate that B-CLL cells can be rescued from apoptosis through an autocrine process involving BAFF, APRIL, and their receptors, and inhibiting BAFF and APRIL pathways may be of therapeutic value for B- CLL treatment.
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BH3 Mimetics: Status of the Field and New Developments
  • C. Billard
  • Biology, Chemistry
    Molecular Cancer Therapeutics
  • 23 August 2013
TLDR
The identification of molecular determinants responsible for the specific interactions between BH3 motifs and the binding grooves of prosurvival proteins and the characterization of new compounds and particularly BH2 mimetics that antagonize either selectively MCL-1 or BCL-2 or a broad range of ProsurVival proteins are presented.
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Types I and II interferons upregulate the costimulatory CD80 molecule in monocytes via interferon regulatory factor-1.
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Role of BAFF and APRIL in human B‐cell chronic lymphocytic leukaemia
TLDR
Two related members of the tumour necrosis factor family, BAFF and APRIL, already known for their crucial role in normal B‐cell survival, differentiation and apoptosis, were recently shown to be expressed by B‐CLL cells.
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New dimension in therapeutic targeting of BCL-2 family proteins
TLDR
The latest developments in the field of targeting BCL-2 family proteins highlight several new antagonists of prosurvival proteins as well as direct activators of proapoptotic proteins that open up novel prospects for the development of BH3 mimetic anticancer drugs.
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Pro-apoptotic properties of hyperforin in leukemic cells from patients with B-cell chronic lymphocytic leukemia
TLDR
The effects of the hyperforin, a natural phloroglucinol purified from Hypericum perforatum, were investigated ex vivo on leukemic cells from patients with B-cell chronic lymphocytic leukemia and indicated that HF-promoted apoptosis of B-CLL cells was mostly caspase dependent.
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Design of novel BH3 mimetics for the treatment of chronic lymphocytic leukemia
  • C. Billard
  • Biology, Chemistry
    Leukemia
  • 1 September 2012
TLDR
Two novel BH3 mimetics that can specifically bind to and antagonize Mcl-1 (a crucial antiapoptotic factor in CLL) have recently been discovered and the evaluation of this type of compound’s clinical impact can now be considered.
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Comparative Antiproliferative and Apoptotic Effects of Resveratrol, ϵ-viniferin and Vine-shots Derived Polyphenols (Vineatrols) on Chronic B Lymphocytic Leukemia Cells and Normal Human Lymphocytes
TLDR
The data indicate that vine-shoots may be a convenient and natural source of material for the purification of resveratrol and other polyphenolic compounds of putative therapeutic interest.
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Abnormal properties of skin fibroblasts from patients with breast cancer
TLDR
It is found that multiple subcultivations in overcrowded culture conditions cause the selection of a fibroblastic cell subset with greater growth potential which, in the cell strain tested, could invade foreigh tissus in vitro.
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