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2',6'-pipecoloxylidide

Known as: 2-piperidinecarboxamide, N-(2,6-dimethylphenyl)-, Desbutylbupivacaine, pipecolylxylidine-2',6' 
National Institutes of Health

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Broader (1)

Bupivacaine
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2006
2006
Effects of premedication medicines on the formation of the CYP3A4-dependent metabolite of ropivacaine, 2', 6'-Pipecoloxylidide, on human liver microsomes in vitro.
Ropivacaine is a relatively new amide-type local anaesthetic, mainly used for surgery and postoperative pain relief. In this… 
1999
1999
Stereoselective urinary excretion of bupivacaine and its metabolites during epidural infusion.
A sensitive and efficient chiral assay for bupivacaine and its three principal metabolites desbutylbupivacaine, 4… 
1998
1998
High-performance liquid chromatographic determination of ropivacaine, 3-hydroxy-ropivacaine, 4-hydroxy-ropivacaine and 2',6'-pipecoloxylidide in plasma.
1996
1996
Effects of calcium antagonists on binding of local anesthetics to plasma proteins and erythrocytes in mice.
This study was designed to document possible changes in the binding of bupivacaine (BV), lidocaine (LC) and their main… 
1995
1995
Kinetics of bupivacaine after clonidine pretreatment in mice
Previous studies have reported that clonidine pretreatment causes an increase in the local anaesthetic activity of bupivacaine… 
1994
1994
Cigarette smoke increases bupivacaine metabolism in rats
This study was designed to document possible changes in bupivacaine kinetics in rats after exposure to cigarette smoke. Rats (n… 
1994
1994
ACUTE TOXICITY OF BUPIVACAINE METABOLITES IN MICE
1. This study was designed to document the acute toxicity of two metabolites of bupivacaine, desbutylbupivacaine (2,6… 
1994
1994
Bupivacaine kinetics during hyperthermia in rats
The aim of this study was to document possible alterations of bupivacaine pharmacokinetic behaviour in rats during hyperthermia… 
1992
1992
Acute cardiovascular and central nervous system toxicity of bupivacaine and desbutylbupivacaine in the rat
Desbutylbupivacaine, a major metabolite of bupivacaine, is known to accumulate during long‐term continuous infusion blocks in man… 
1988
1988
Lack of effect of cimetidine on the pharmacokinetics of bupivacaine in healthy subjects.
1. The possibility of a pharmacokinetic interaction between the H2-receptor antagonist cimetidine and the long-acting local… 
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