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Benzoquinone ansamycins are important leads for the discovery of novel inhibitors of heat shock protein 90 (Hsp90), a promising… Expand BACKGROUND/PURPOSE
Nuclear localization of β-catenin is known to associate with malignant transformation of many squamous cell… Expand Abstract: Narrow‐band ultraviolet‐B (UVB) radiation is an effective treatment for vitiligo vulgaris. However, the mechanisms of… Expand OBJECTIVES
To determine whether pharmacological induction of heat shock proteins (HSPs) by herbimycin-A (a tyrosine-kinase… Expand PURPOSE
Recent advances in the understanding of the biologic mechanisms of vascular diseases suggest that multifactorial… Expand Heat shock protein (hsp) induction by stressful stimuli such as heat and ischemia is known to protect cardiac cells from severe… Expand Neutrophils provide an attractive model with which to characterize cellular effects of phosphatidic acid (PA) independently of… Expand Herbimycin A, a benzoquinonoid ansamycin antibiotic, reduces intracellular phosphorylation by some protein tyrosine kinases and… Expand Thrombospondin-1 (TSP-1) is an extracellular glycoprotein that plays a role in neoplasia, cell growth, and differentiation. We… Expand A new benzoquinonoid ansamycin, herbimycin B was isolated from the culture broth of Streptomyces hygroscopicus No. AM-3672, a… Expand