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Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1
Parkinson's disease (PD) is a neurodegenerative disorder characterized by degeneration of dopaminergic neurons in the substantia nigra. We previously mapped a locus for a rare familial form of PD toExpand
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Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction.
BACKGROUND To test the hypothesis that the heat shock response is associated with myocardial salvage, the heat stress protein (HSP) content of cardiac tissue was increased by either ischemic orExpand
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Transcription factors: an overview.
  • D. Latchman
  • Biology, Medicine
  • The international journal of biochemistry & cell…
  • 1 October 1993
This special issue of the International Journal of Biochemistry and Cell Biology contains a series of review articles and original papers dealing with the topic of transcription factors. The purposeExpand
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PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-Induced Cell Death
Summary Mutations in PINK1 cause autosomal recessive Parkinson's disease. PINK1 is a mitochondrial kinase of unknown function. We investigated calcium homeostasis and mitochondrial function inExpand
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PINK1 protein in normal human brain and Parkinson's disease.
Parkinson's disease is a common incurable neurodegenerative disease whose molecular aetiology remains unclear. The identification of Mendelian genes causing rare familial forms of Parkinson's diseaseExpand
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Effect of aging on the ability of preconditioning to protect rat hearts from ischemia-reperfusion injury.
Ischemic preconditioning (IP) reduces infarct size in young animals; however, its impact on aging is underinvestigated. The effect of variations in IP stimuli was studied in young, middle-aged, andExpand
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Voltage-Gated Sodium Channel Expression and Potentiation of Human Breast Cancer Metastasis
Purpose: Ion channel activity is involved in several basic cellular behaviors that are integral to metastasis (e.g., proliferation, motility, secretion, and invasion), although their contribution toExpand
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Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress
Following our identification of PTEN‐induced putative kinase 1 (PINK1) gene mutations in PARK6‐linked Parkinson's disease (PD), we have recently reported that PINK1 protein localizes to Lewy bodiesExpand
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Heat shock proteins and cardiac protection.
  • D. Latchman
  • Medicine
  • Cardiovascular research
  • 1 September 2001
The heat shock proteins (hsps) are expressed in normal cells but their expression is enhanced by a number of different stresses including heat and ischaemia. They play important roles in chaperoningExpand
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Bimoclomol, a heat shock protein co-inducer, acts by the prolonged activation of heat shock factor-1.
The novel hydroxylamine derivative, bimoclomol, has been shown previously to act as a co-inducer of several heat shock proteins (Hsp-s), enhancing the amount of these proteins produced following aExpand
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