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- Publications
- Influence
Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1
- E. M. Valente, P. Abou-Sleiman, +19 authors N. Wood
- Biology, Medicine
- Science
- 21 May 2004
Parkinson's disease (PD) is a neurodegenerative disorder characterized by degeneration of dopaminergic neurons in the substantia nigra. We previously mapped a locus for a rare familial form of PD to… Expand
Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction.
- M. Marber, D. Latchman, J. Walker, D. Yellon
- Medicine
- Circulation
- 1 September 1993
BACKGROUND
To test the hypothesis that the heat shock response is associated with myocardial salvage, the heat stress protein (HSP) content of cardiac tissue was increased by either ischemic or… Expand
PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-Induced Cell Death
- S. Gandhi, A. Wood-Kaczmar, +9 authors A. Abramov
- Biology, Medicine
- Molecular cell
- 13 March 2009
Summary Mutations in PINK1 cause autosomal recessive Parkinson's disease. PINK1 is a mitochondrial kinase of unknown function. We investigated calcium homeostasis and mitochondrial function in… Expand
Transcription factors: an overview.
- D. Latchman
- Biology, Medicine
- The international journal of biochemistry & cell…
- 1 October 1993
This special issue of the International Journal of Biochemistry and Cell Biology contains a series of review articles and original papers dealing with the topic of transcription factors. The purpose… Expand
PINK1 protein in normal human brain and Parkinson's disease.
- S. Gandhi, M. M. Muqit, +11 authors T. Revesz
- Biology, Medicine
- Brain : a journal of neurology
- 1 July 2006
Parkinson's disease is a common incurable neurodegenerative disease whose molecular aetiology remains unclear. The identification of Mendelian genes causing rare familial forms of Parkinson's disease… Expand
Effect of aging on the ability of preconditioning to protect rat hearts from ischemia-reperfusion injury.
- D. Schulman, D. Latchman, D. Yellon
- Medicine
- American journal of physiology. Heart and…
- 1 October 2001
Ischemic preconditioning (IP) reduces infarct size in young animals; however, its impact on aging is underinvestigated. The effect of variations in IP stimuli was studied in young, middle-aged, and… Expand
Voltage-Gated Sodium Channel Expression and Potentiation of Human Breast Cancer Metastasis
- S. P. Fraser, J. Diss, +20 authors M. Djamgoz
- Biology, Medicine
- Clinical Cancer Research
- 1 August 2005
Purpose: Ion channel activity is involved in several basic cellular behaviors that are integral to metastasis (e.g., proliferation, motility, secretion, and invasion), although their contribution to… Expand
Novel cell lines display properties of nociceptive sensory neurons
- J. Wood, S. Bevan, +8 authors S. Wheatley
- Biology, Medicine
- Proceedings of the Royal Society of London…
- 22 September 1990
Hybrid cell lines derived from neonatal rat dorsal root ganglia neurons fused with the mouse neuroblastoma N18Tg2 exhibit sensory neuron-like properties not displayed by the parental neuroblastoma.… Expand
Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress
- M. M. Muqit, P. Abou-Sleiman, +16 authors D. Latchman
- Biology, Medicine
- Journal of neurochemistry
- 1 July 2006
Following our identification of PTEN‐induced putative kinase 1 (PINK1) gene mutations in PARK6‐linked Parkinson's disease (PD), we have recently reported that PINK1 protein localizes to Lewy bodies… Expand
Urocortin Protects against Ischemic and Reperfusion Injury via a MAPK-dependent Pathway*
- B. Brar, A. K. Jonassen, +5 authors D. Latchman
- Medicine, Biology
- The Journal of Biological Chemistry
- 24 March 2000
Urocortin (UCN) is a peptide related to hypothalamic corticotrophin-releasing hormone and binds with high affinity to corticotrophin-releasing hormone receptor-2β, which is expressed in the heart. In… Expand