D. Latchman

Publications670
h-index85
Citations28,526
Highly Influential Citations969
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Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1
Parkinson's disease (PD) is a neurodegenerative disorder characterized by degeneration of dopaminergic neurons in the substantia nigra. We previously mapped a locus for a rare familial form of PD to… Expand
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Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction.
BACKGROUND To test the hypothesis that the heat shock response is associated with myocardial salvage, the heat stress protein (HSP) content of cardiac tissue was increased by either ischemic or… Expand
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PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-Induced Cell Death
Summary Mutations in PINK1 cause autosomal recessive Parkinson's disease. PINK1 is a mitochondrial kinase of unknown function. We investigated calcium homeostasis and mitochondrial function in… Expand
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Transcription factors: an overview.
  • D. Latchman
  • Biology, Medicine
  • The international journal of biochemistry & cell…
  • 1 October 1993
This special issue of the International Journal of Biochemistry and Cell Biology contains a series of review articles and original papers dealing with the topic of transcription factors. The purpose… Expand
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PINK1 protein in normal human brain and Parkinson's disease.
Parkinson's disease is a common incurable neurodegenerative disease whose molecular aetiology remains unclear. The identification of Mendelian genes causing rare familial forms of Parkinson's disease… Expand
  • 312
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  • PDF
Effect of aging on the ability of preconditioning to protect rat hearts from ischemia-reperfusion injury.
Ischemic preconditioning (IP) reduces infarct size in young animals; however, its impact on aging is underinvestigated. The effect of variations in IP stimuli was studied in young, middle-aged, and… Expand
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Voltage-Gated Sodium Channel Expression and Potentiation of Human Breast Cancer Metastasis
Purpose: Ion channel activity is involved in several basic cellular behaviors that are integral to metastasis (e.g., proliferation, motility, secretion, and invasion), although their contribution to… Expand
  • 350
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Novel cell lines display properties of nociceptive sensory neurons
Hybrid cell lines derived from neonatal rat dorsal root ganglia neurons fused with the mouse neuroblastoma N18Tg2 exhibit sensory neuron-like properties not displayed by the parental neuroblastoma.… Expand
  • 201
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Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress
Following our identification of PTEN‐induced putative kinase 1 (PINK1) gene mutations in PARK6‐linked Parkinson's disease (PD), we have recently reported that PINK1 protein localizes to Lewy bodies… Expand
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Urocortin Protects against Ischemic and Reperfusion Injury via a MAPK-dependent Pathway*
Urocortin (UCN) is a peptide related to hypothalamic corticotrophin-releasing hormone and binds with high affinity to corticotrophin-releasing hormone receptor-2β, which is expressed in the heart. In… Expand
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