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Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1
TLDR
The identification of two homozygous mutations affecting the PINK1 kinase domain in three consanguineous PARK6 families provide a direct molecular link between mitochondria and the pathogenesis of PD.
Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction.
TLDR
It is suggested that stress protein elevation, rather than the nonspecific effects of thermal or ischemic stress, may be responsible for the myocardial protection seen in this model.
Transcription factors: an overview.
  • D. Latchman
  • Biology
    The international journal of biochemistry & cell…
  • 1 October 1993
PINK1 protein in normal human brain and Parkinson's disease.
TLDR
In vivo morphological and biochemical evidence is provided for the first time to support a mitochondrial localization of PINK1 and underpin the significance of mitochondrial dysfunction in the pathogenesis of nigral cell degeneration in Parkinson's disease.
Voltage-Gated Sodium Channel Expression and Potentiation of Human Breast Cancer Metastasis
TLDR
Investigating voltage-gated Na+ channel expression and its possible role in human breast cancer found up-regulation of neonatal Nav1.5 protein in its newly identified “neonatal” splice form could serve both as a novel marker of the metastatic phenotype and a therapeutic target.
Effect of aging on the ability of preconditioning to protect rat hearts from ischemia-reperfusion injury.
TLDR
The results suggest that there are defects within the IP signaling cascade of the aged heart, and any IP-like mimetics to the benefit of an aging population should be considered.
Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress
TLDR
A cellular model system of LBs, namely induction of aggresomes, is used to determine how a mitochondrial protein, such as PINK1, can localize to aggregates and provide valuable insights into the mechanisms of LB formation in PD.
Activity of herpes simplex virus type 1 latency-associated transcript (LAT) promoter in neuron-derived cells: evidence for neuron specificity and for a large LAT transcript
TLDR
It is shown that promoter activity associated with the herpes simplex virus type 1 latency-associated transcript (LAT) had neuronal specificity and was located over 660 nucleotides upstream from the 5' end of the previously mapped 2-kilobase (kb) LAT.
Heat shock proteins and cardiac protection.
  • D. Latchman
  • Biology
    Cardiovascular research
  • 1 September 2001
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