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A new alkaloid AM-2282 OF Streptomyces origin. Taxonomy, fermentation, isolation and preliminary characterization.
The producing strain, AM-2282 was classified as a new species and the name, Streptomyces staurosporeus AWAYA, TAKAHASHI and OMURA, nov. is proposed to show antimicrobial activity against fungi and yeast.
A bacterial platform for fermentative production of plant alkaloids
An Escherichia coli fermentation system is developed that yields plant alkaloids from simple carbon sources, using selected enzymes to construct a tailor-made biosynthetic pathway.
Total biosynthesis of opiates by stepwise fermentation using engineered Escherichia coli
It is demonstrated that Escherichia coli serves as an efficient, robust and flexible platform for total opiate synthesis and the biosynthesis of hydrocodone, a clinically important opioid, by adding two genes to the thebaine production system.
Byelyankacin: A Novel Melanogenesis Inhibitor Produced by Enterobacter sp. B20
A novel melanogenesis inhibitor, byelyankacin, was isolated from the fermentation broth of a bacterial strain and determined as (E)-4-(2-isocyanovinyl)phenyl α-L-rhamnopyranoside on the basis of spectroscopic data.
Tracing microbiota changes in yamahai-moto, the traditional Japanese sake starter
- T. Koyanagi, A. Nakagawa, H. Kumagai
- Medicine, BiologyBioscience, biotechnology, and biochemistry
- 1 February 2016
This is the first report, though one case study, to show how the early stage microbiota in Japanese yamahai-moto is varyingly controlled without nitrate-reducing bacteria using next-generation sequencing.
Structure of lactacystin, a new microbial metabolite which induces differentiation of neuroblastoma cells.
The structure elucidation of lactacystin by NMRspectroscopic and X-ray crystallographic analyses is reported, which causes a transient increase of the intracellular CAMPlevel in Neuro 2A cells and morphological changes including neuritogenesis.
Cervinomycin A1 and A2, new antibiotics active against anaerobes, produced by Streptomyces cervinus sp. nov.
Two new antibiotics, cervinomycin A1 and A2, were isolated from the culture filtrate of strain AM-5344, a soil isolate. The strain was found to belong to a new species of the genus Streptomyces for…
Bench-top fermentative production of plant benzylisoquinoline alkaloids using a bacterial platform.
The plant secondary metabolites benzylisoquinoline alkaloids (BIAs) have diverse pharmaceutical activities, and some are used medicinally (e.g., morphine, codeine, berberine). Recently, we…
Structure of herbimycin A new ansamycin antibiotic