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SERPINA1 gene

Known as: ANTITRYPSIN, A1AT, ANTI-ELASTASE 
This gene plays a role in both coagulation and the regulation of proteolysis.
National Institutes of Health

Related topics

Related topics

7 relations
Protein Degradation InhibitionRegulation of ProteolysisSERPINA1 wt AlleleSERPINA11 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Linkage Specific Fucosylation of Alpha-1-Antitrypsin in Liver Cirrhosis and Cancer Patients: Implications for a Biomarker of Hepatocellular Carcinoma
Background We previously reported increased levels of protein-linked fucosylation with the development of liver cancer and… 
Highly Cited
2006
Highly Cited
2006
High levels of persistent expression of alpha1-antitrypsin mediated by the nonhuman primate serotype rh.10 adeno-associated virus despite preexisting immunity to common human adeno-associated viruses…
Highly Cited
1997
Highly Cited
1997
Evaluation of the differentiation potential of WB-F344 rat liver epithelial stem-like cells in vivo. Differentiation to hepatocytes after transplantation into dipeptidylpeptidase-IV-deficient rat…
After intrahepatic transplantation into livers of adult syngeneic German-strain Fischer 344 rats that are deficient for the bile… 
Highly Cited
1995
Highly Cited
1995
Therapeutic serum concentrations of human alpha‐1‐antitrypsin after adenoviral‐mediated gene transfer into mouse hepatocytes
Alpha‐1‐antitrypsin is a relatively common genetic deficiency that results in early emphysema. The liver as the natural source of… 
Highly Cited
1991
Highly Cited
1991
Effect of dexamethasone on pulmonary inflammation and pulmonary function of ventilator-dependent infants with bronchopulmonary dysplasia.
Seventeen ventilator-dependent premature infants with bronchopulmonary dysplasia (BPD) were enrolled in a double-blind, placebo… 
Highly Cited
1991
Highly Cited
1991
Cathepsin-G and leukocyte elastase inactivate human tumor necrosis factor and lymphotoxin.
Highly Cited
1987
Highly Cited
1987
Non-enzymic glycation of individual plasma proteins in normoglycemic and hyperglycemic patients.
Diabetic patients in poor glycemic control show increased glycation of total plasma proteins, but little is yet known about the… 
Highly Cited
1984
Highly Cited
1984
The competitive effects of serum proteins on cell adhesion.
Binding curves for the adsorption of plasma fibronectin, alpha-1-antitrypsin, alpha-2-macroglobulin, ceruloplasmin, transferrin… 
Highly Cited
1982
Highly Cited
1982
Demonstration of alpha-1-antitrypsin and alpha-1-antichymotrypsin in fibrous histiocytomas using the immunoperoxidase technique.
ABSTRACTUntil recently, the diagnosis and classification of malignant fibrous histiocytomas (MFH) has been based on light- and… 
Highly Cited
1975
Highly Cited
1975
Characterization of α1-Antitrypsin in the Inclusion Bodies from the Liver in α1-Antitrypsin Deficiency
Abstract α1-antitrypsin was isolated from periodic acidSchiffpositive inclusion bodies from the hepatocytes of patients with α1… 
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