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Molecular viral oncology of hepatocellular carcinoma
TLDR
A review of the molecular and cellular mechanisms involved in primary hepatocellular carcinoma, using a viral perspective, finds features that unify HCC occurring in a background of viral hepatitis B and C.
Use of targeted glycoproteomics to identify serum glycoproteins that correlate with liver cancer in woodchucks and humans.
TLDR
It is shown that woodchuck diagnosed with HCC have dramatically higher levels of serum-associated core alpha-1,6-linked fucose, as compared with woodchucks without a diagnosis of HCC, providing a validation of the approach.
MALDI Imaging Mass Spectrometry Profiling of N-Glycans in Formalin-Fixed Paraffin Embedded Clinical Tissue Blocks and Tissue Microarrays
TLDR
The efficacy of using MALDI-IMS glycan profiling to distinguish tumor from non-tumor tissues in a tumor microarray format is demonstrated and has the potential to be applied to any FFPE tissue block or tissue microarray to enable higher throughput analysis of the global changes in N-glycosylation associated with cancers.
Imino sugars inhibit the formation and secretion of bovine viral diarrhea virus, a pestivirus model of hepatitis C virus: implications for the development of broad spectrum anti-hepatitis virus
TLDR
It is shown that in MDBK cells alpha-glucosidase inhibitors prevented the formation and secretion of infectious bovine viral diarrhea virus and data is presented showing that NN-DNJ, compared with NB- DNJ, exhibits a prolonged retention in liver in vivo.
Correlation between herpes simplex virus type 1 rate of reactivation from latent infection and the number of infected neurons in trigeminal ganglia.
TLDR
Analysis of the presence of wild-type herpes simplex virus type 1 (HSV-1) and several latency associated transcript (LAT) region mutants within the trigeminal ganglia of latently infected mice showed that the population of neurons expressing detectable levels of LAT was approximately one-third the total number of viral DNA-containing cells.
Hepatitis B virus (HBV) envelope glycoproteins vary drastically in their sensitivity to glycan processing: evidence that alteration of a single N-linked glycosylation site can regulate HBV secretion.
TLDR
Site-directed mutagenesis provides evidence that virion secretion requires the glycosylation sequon in the pre-S2 domain of M, which highlights the potential role of the M protein oligosaccharide as a therapeutic target.
Characterization of HIV–HBV coinfection in a multinational HIV-infected cohort
TLDR
Screening for HBV in HIV-infected patients in resource-limited settings is important because it is associated with lower CD4+ T-cell counts and in settings in which HBV DNA is not available, HBeAg may be useful to assess the need forHBV treatment.
Treatment of chronic hepadnavirus infection in a woodchuck animal model with an inhibitor of protein folding and trafficking
TLDR
It is provided the first evidence that glucosidase inhibitors can be used in vivo to alter specific steps in the N-linked glycosylation pathway and that this inhibition has anti-viral effects.
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