10-deacetyltaxol

Known as: 10-deacetyl-7-epi-taxol, 10-deacetyl-7-epitaxol, Benzenepropanoic acid, beta-(benzoylamino)-alpha-hydroxy-, 12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester, (2aR-(2aalpha,4beta,4abeta,6beta,9alpha(alphaR*,betaS*),11alpha,12alpha,12aalpha,12balpha))- 
An analog of paclitaxel with antineoplastic activity. 10-Deacetyltaxol binds to and stabilizes the resulting microtubules, thereby inhibiting… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1981-2017
02419812017

Papers overview

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2017
2017
The natural concentration of the anticancer drug Taxol is about 0.02% in yew trees, whereas that of its analogue 7-β-xylosyl-10… (More)
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2015
2015
Paclitaxel content in yew tree is extremely low, causing a worldwide shortage of this important anticancer drug. Yew tree can… (More)
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2013
2013
Paclitaxel, a natural antitumor compound, is produced by yew trees at very low concentrations, causing a worldwide shortage of… (More)
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2012
2012
This method development was to confirm the fatal ingestion of toxic yew plant material in postmortem samples (stomach content… (More)
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2008
2008
Paclitaxel and other taxanes have complex structures including the presence of numerous hydrolytically sensitive ester groups and… (More)
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2006
2006
BACKGROUND Taxol is an effective antineoplastic agent, originally extracted from the bark of Taxus brevifolia with a low yield… (More)
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1995
1995
This study examined the effect of dexamethasone (DEX), 100 mg/kg/day for 3 days, on [3H]taxol metabolism in liver microsomes and… (More)
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1994
1994
Four new taxoids were isolated from cell cultures of Taxus baccata. Their structures were elucidated by spectroscopic analyses… (More)
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1982
1982
The isolation of two taxanes from Taxus brevifolia Nutt. is described, together with the isolation of two acetylated taxol… (More)
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1981
1981
Activity-guided, chromatographic fractionation for a polar extract of Taxus wallichiana Zucc. (originally identified as… (More)
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