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Site-Specific Ribose Methylation of Preribosomal RNA: A Novel Function for Small Nucleolar RNAs
TLDR
The conclusion that sno-RNAs function in covalent modification of the sugar moieties of ribonucleotides demonstrates that eukaryotic small nuclear RNAs have a more versatile cellular function than earlier anticipated. Expand
The complete nucleotide sequence of mouse 28S rRNA gene. Implications for the process of size increase of the large subunit rRNA in higher eukaryotes.
TLDR
The complete nucleotide sequence of the mouse 28S rRNA gene is determined and it is indicated that the potential for major variations in size during the evolution has been restricted to a unique set of a few sites within a largely conserved secondary structure core. Expand
The expanding snoRNA world.
TLDR
Recent characterization of homologs of eukaryotic modification guide snoRNAs in Archaea reveals the ancient origin of these non-coding RNA families and offers new perspectives as to their range of function. Expand
Identification of brain-specific and imprinted small nucleolar RNA genes exhibiting an unusual genomic organization.
TLDR
Three C/D-box small nucleolar RNAs (snoRNAs) and one H/ACA-box snoRNA in mouse and human are identified, demonstrating their paternal imprinting status and pointing to their potential role in the etiology of PWS. Expand
Identification of 86 candidates for small non-messenger RNAs from the archaeon Archaeoglobus fulgidus
TLDR
This study identifies four candidates for H/ACA small RNAs in an archaeal species that are predicted to guide a total of six rRNA pseudouridylations, and demonstrates the importance of snmRNAs in all three domains of life. Expand
Binding of L7Ae protein to the K-turn of archaeal snoRNAs: a shared RNA binding motif for C/D and H/ACA box snoRNAs in Archaea.
TLDR
A triple role for L7Ae protein in Archaea, e.g. in ribosomes as well as H/ACA and C/D box sRNP biogenesis and function by binding to the K-turn motif is suggested. Expand
RNomics: an experimental approach that identifies 201 candidates for novel, small, non‐messenger RNAs in mouse
TLDR
Of the 88 RNAs not belonging to either snoRNA subclass, at least 26 are probably derived from truncated heterogeneous nuclear RNAs (hnRNAs) or mRNAs, and may represent rare examples of transcribed SINEs. Expand
Imprinted microRNA genes transcribed antisense to a reciprocally imprinted retrotransposon-like gene
TLDR
It is shown that the imprinted mouse distal chromosome 12 locus encodes two miRNA genes expressed from the maternally inherited chromosome and antisense to a retrotransposon-like gene (Rtl1) expressed only from the paternal allele. Expand
RNomics in Drosophila melanogaster: identification of 66 candidates for novel non-messenger RNAs
TLDR
By generating a specialised cDNA library from four different developmental stages of Drosophila melanogaster, 66 candidates for small non-messenger RNAs (snmRNAs) are identified and confirmed their expression by northern blot analysis and detection of two RNA species from this group implies that certain snmRNA species are processed from alternatively spliced pre-m RNAs. Expand
Intranuclear distribution of poly(A) RNA determined by electron microscope in situ hybridization.
TLDR
The results are discussed in relation to the role of perichromatin fibrils in splicing of pre-mRNA and to the possible involvement of interchromatin granules in the assembly of mature spliceosomes as well as in sorting and/or coordination of RNA molecules to be transported to the cytoplasm. Expand
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