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1-hexylcarbamoyl-5-fluorouracil

Known as: 1(2H)-Pyrimidinecarboxamide, 5-fluoro-N-hexyl-3,4-dihydro-2,4-dioxo-, CARMOFUR, HCFU 
An antimetabolite (pyrimidine analogue) antineoplastic derivative of 5-fluorouracil. (NCI)
National Institutes of Health

Related topics

Related topics

5 relations

Broader (2)

Antineoplastic AgentsFluorouracil

Narrower (1)

Mifurol
NCIt Antineoplastic Agent Terminologyanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Acid ceramidase is a novel drug target for pediatric brain tumors
Pediatric brain tumors are the most common solid tumors in children and are also a leading culprit of cancer-related fatalities… 
2006
2006
Randomized trial of the efficacy of adjuvant chemotherapy for colon cancer with combination therapy incorporating the oral pyrimidine 1-hexylcarbamoyl-5-fluorouracil
Background and aimsThe purpose of the present trial was to clarify the efficacy of postoperative adjuvant chemotherapy including… 
2004
2004
Neuropathologic study on chronic neurotoxicity of 5-fluorouracil and its masked compounds in dogs
Summary5-Fluorouracil (FU) and its masked compounds tegafur (FT) and carmofur (HCFU) were administered orally to Beagle dogs… 
1996
1996
Postoperative chemotherapy for colorectal cancer by combining 5‐fluorouracil infusion and 1‐hexylcarbamoyl‐5‐fluorouracil administration after curative resection
Colorectal cancer is one of the major malignant diseases and, recently, its incidence appears to be increasing. Surgical… 
1988
1988
Colorectal carcinomain vitro is more sensitive to 1-hexylcarbamoyl-5-fluorouracil compared with six other antitumor drugs: Carboquone, adriamycin®, mitomycin C, aclacinomycin A, cisplatin, 5…
The sensitivity to 1-hexylcarbamoyl-5-fluorouracil (HCFU) of 25 colorectal cancer tissues was compared with that of six antitumor… 
1981
1981
Metabolism of 1-hexylcarbamoyl-5-fluorouracil (HCFU), a new antitumour agent, in rats, rabbits and dogs.
1. 1-Hexylcarbamoyl-5-fluoro[6-14C]uracil (14C-HCFU) administered orally to rats, rabbits and dogs at a dose of 20 mg/kg was well… 
1980
1980
Phase I study of a new antitumor drug, 1-hexylcarbamoyl-5-fluorouracil (HCFU), administered orally: an HCFU clinical study group report.
A phase I study of a new fluorinated pyrimidine, 1-hexylcarbamoyl-5-fluorouracil (HCFU), was performed by a multi-institutional… 
1978
1978
Metabolic fate of 1-hexylcarbamoyl-5-fluorouracil in rats.
1. The metabolic fate of a new antitumour agent, 1-hexylcarbamoyl-5-fluoro [6-14C]uracil (14C-HCFU) in rats after oral… 
1978
1978
Antitumor activity of 1-hexylcarbamoyl-5-fluorouracil in Lewis lung carcinoma and B16 melanoma.
Antitumor activity of 1-hexylcarbamoyl-5-fluorouracil (HCFU) against Lewis lung carcinoma and B16 melanoma by long-term oral… 
1976
1976
Antitumor activity of 1-hexylcarbamoyl-5-fluorouracil in a variety of experimental tumors.
Antitumor activity of 1-hexylcarbamoyl-5-fluorouracil against various tumors was examined. Therapeutic ratio (ILSmax/ILS30) in L… 
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