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1-hexylcarbamoyl-5-fluorouracil

Known as: 1(2H)-Pyrimidinecarboxamide, 5-fluoro-N-hexyl-3,4-dihydro-2,4-dioxo-, CARMOFUR, HCFU 
An antimetabolite (pyrimidine analogue) antineoplastic derivative of 5-fluorouracil. (NCI)
National Institutes of Health

Related topics

Related topics

5 relations

Broader (2)

Antineoplastic AgentsFluorouracil

Narrower (1)

Mifurol
NCIt Antineoplastic Agent Terminologyanalogs & derivatives

Papers overview

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2017
2017
Induction of oxidative stress by anticancer drugs in the presence and absence of cells.
Reactive oxygen species (ROS) are generated in the cell through multiple mechanisms. Intracellular ROS are rapidly detoxified by… Expand
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2016
2016
Screening a Commercial Library of Pharmacologically Active Small Molecules against Staphylococcus aureus Biofilms
ABSTRACT It is now well established that bacterial infections are often associated with biofilm phenotypes that demonstrate… Expand
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Highly Cited
2013
Highly Cited
2013
Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity
The expression of acid ceramidase (AC) – a cysteine amidase that hydrolyses the proapoptotic lipid ceramide – is abnormally high… Expand
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2013
2013
Discovery of a new class of highly potent inhibitors of acid ceramidase: synthesis and structure-activity relationship (SAR).
Acid ceramidase (AC) is an intracellular cysteine amidase that catalyzes the hydrolysis of the lipid messenger ceramide. By… Expand
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Highly Cited
2009
Highly Cited
2009
Suppression of growth, migration and invasion of highly-metastatic human breast cancer cells by berbamine and its molecular mechanisms of action
BackgroundBreast cancer is the second leading cause of cancer related deaths among females worldwide. Berbamine (BER), a kind of… Expand
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2009
2009
IL-27 Abrogates Receptor Activator of NF-κB Ligand-Mediated Osteoclastogenesis of Human Granulocyte-Macrophage Colony-Forming Unit Cells through STAT1-Dependent Inhibition of c-Fos1
IL-27 was first discovered as a factor supporting initial Th1 immune responses. Subsequent studies revealed that this cytokine… Expand
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Highly Cited
2006
Highly Cited
2006
Delivery of hydrophobised 5-fluorouracil derivative to brain tissue through intravenous route using surface modified nanogels
Random copolymeric micelles composed of N-isopropylacrylamide (NIPAAM) and N-vinylpyrrolidone (VP) cross-linked with N,N… Expand
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Highly Cited
2001
Highly Cited
2001
Randomized, controlled trial of lateral node dissectionvs. nerve-preserving resection in patients with rectal cancer after preoperative radiotherapy
PURPOSE: The effectiveness of preoperative radiation therapy for advanced lower rectal carcinoma to preserve the function of… Expand
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Highly Cited
2001
Highly Cited
2001
Adjuvant chemotherapy after resection of hepatocellular carcinoma causes deterioration of long-term prognosis in cirrhotic patients: metaanalysis of three randomized controlled trials.
BACKGROUND The goal of the current study was use metaanalysis to evaluate the effect of postoperative adjuvant chemotherapy after… Expand
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1999
1999
Adjuvant therapy with oral fluoropyrimidines as main chemotherapeutic agents after curative resection for colorectal cancer: individual patient data meta-analysis of randomized trials.
BACKGROUND Oral 5-fluorouracil and its prodrugs (tegafur, carmofur) is now being studied for adjuvant chemotherapy of curatively… Expand
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