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Emodin, 1,3,8-trihydroxy-6-methyl-anthraquinone, is an anthraquinone derivative from the roots of Rheum officinale Baill that has… Expand Expression of the farnesoid X receptor (FXR; NR1H4) is limited to the liver, intestine, kidney, and adrenal gland. However, the… Expand Farnesoid X receptor (FXR) is a bile acid-activated transcription factor that is a member of the nuclear hormone receptor… Expand Cholestasis may result from a failure in bile secretion in hepatocytes or ductular cells, or from a blockade to the free bile… Expand The metabolite profiles from livers of toxin-treated rats were investigated using high resolution 1H NMR spectroscopy of aqueous… Expand We present here a novel integrative metabonomic approach to probe toxic effects of drugs in experimental animals using alpha… Expand MRP2 is a canalicular transporter in hepatocytes mediating the transport of a wide spectrum of amphipathic compounds. This… Expand BACKGROUND/AIMS/METHODS
Since in rat experiments, activation of progenitor cells is seen in conditions associated with hepatocyte… Expand Hepatocyte growth factor, a potent mitogen for mature hepatocytes in vitro, seems to function as a hepatotrophic factor for liver… Expand alpha-Naphthylisothiocyanate (ANIT) causes cholestasis and injury to bile duct epithelium and hepatic parenchymal cells in rats… Expand