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1-Naphthylisothiocyanate

Known as: Naphthalene, 1-isothiocyanato-, 1 Naphthylisothiocyanate, alpha Naphthylisothiocyanate 
A tool for the study of liver damage which causes bile stasis and hyperbilirubinemia acutely and bile duct hyperplasia and biliary cirrhosis… 
National Institutes of Health

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9 relations

Narrower (2)

2-naphthylisothiocyanate4-N,N-dimethylamino-1-naphthylisothiocyanate
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

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Highly Cited
2006
Highly Cited
2006
FXR regulates organic solute transporters α and β in the adrenal gland, kidney, and intestine Published, JLR Papers in Press, October 26, 2005.
Expression of the farnesoid X receptor (FXR; NR1H4) is limited to the liver, intestine, kidney, and adrenal gland. However, the… 
Highly Cited
2003
Highly Cited
2003
Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis.
Farnesoid X receptor (FXR) is a bile acid-activated transcription factor that is a member of the nuclear hormone receptor… 
Review
2003
Review
2003
Cholestasis: human disease and experimental animal models.
Highly Cited
2002
Highly Cited
2002
NMR and pattern recognition studies on liver extracts and intact livers from rats treated with alpha-naphthylisothiocyanate.
Highly Cited
2001
Highly Cited
2001
NMR and pattern recognition studies on the time-related metabolic effects of alpha-naphthylisothiocyanate on liver, urine, and plasma in the rat: an integrative metabonomic approach.
We present here a novel integrative metabonomic approach to probe toxic effects of drugs in experimental animals using alpha… 
Highly Cited
2001
Highly Cited
2001
Role of MRP2 and GSH in intrahepatic cycling of toxins.
Highly Cited
1998
Highly Cited
1998
Hepatic OV-6 expression in human liver disease and rat experiments: evidence for hepatic progenitor cells in man.
Review
1995
Review
1995
The in vivo and in vitro protective properties of taurine.
Review
1994
Review
1994
Novel mechanisms in chemically induced hepatotoxicity 1
This review focuses on cellular events that modulate hepatotoxicity subsequent to initial liver insult. Cellular events that… 
Highly Cited
1991
Highly Cited
1991
An antibody to neutrophils attenuates alpha-naphthylisothiocyanate-induced liver injury.
alpha-Naphthylisothiocyanate (ANIT) causes cholestasis and injury to bile duct epithelium and hepatic parenchymal cells in rats… 
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