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1-Naphthylisothiocyanate

Known as: Naphthalene, 1-isothiocyanato-, 1 Naphthylisothiocyanate, alpha Naphthylisothiocyanate 
A tool for the study of liver damage which causes bile stasis and hyperbilirubinemia acutely and bile duct hyperplasia and biliary cirrhosis… Expand
National Institutes of Health

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Related topics

9 relations

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2-naphthylisothiocyanate4-N,N-dimethylamino-1-naphthylisothiocyanate
In Bloodagonistsanalogs & derivativesantagonists & inhibitors
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Papers overview

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Highly Cited
2008
Highly Cited
2008
Exploration of Emodin to treat alpha-naphthylisothiocyanate-induced cholestatic hepatitis via anti-inflammatory pathway.
Emodin, 1,3,8-trihydroxy-6-methyl-anthraquinone, is an anthraquinone derivative from the roots of Rheum officinale Baill that has… Expand
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Highly Cited
2006
Highly Cited
2006
FXR regulates organic solute transporters α and β in the adrenal gland, kidney, and intestine Published, JLR Papers in Press, October 26, 2005.
Expression of the farnesoid X receptor (FXR; NR1H4) is limited to the liver, intestine, kidney, and adrenal gland. However, the… Expand
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Highly Cited
2003
Highly Cited
2003
Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis.
Farnesoid X receptor (FXR) is a bile acid-activated transcription factor that is a member of the nuclear hormone receptor… Expand
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Review
2003
Review
2003
Cholestasis: human disease and experimental animal models.
Cholestasis may result from a failure in bile secretion in hepatocytes or ductular cells, or from a blockade to the free bile… Expand
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Highly Cited
2002
Highly Cited
2002
NMR and pattern recognition studies on liver extracts and intact livers from rats treated with alpha-naphthylisothiocyanate.
The metabolite profiles from livers of toxin-treated rats were investigated using high resolution 1H NMR spectroscopy of aqueous… Expand
Highly Cited
2001
Highly Cited
2001
NMR and pattern recognition studies on the time-related metabolic effects of alpha-naphthylisothiocyanate on liver, urine, and plasma in the rat: an integrative metabonomic approach.
We present here a novel integrative metabonomic approach to probe toxic effects of drugs in experimental animals using alpha… Expand
Highly Cited
2001
Highly Cited
2001
Role of MRP2 and GSH in intrahepatic cycling of toxins.
MRP2 is a canalicular transporter in hepatocytes mediating the transport of a wide spectrum of amphipathic compounds. This… Expand
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Highly Cited
1998
Highly Cited
1998
Hepatic OV-6 expression in human liver disease and rat experiments: evidence for hepatic progenitor cells in man.
BACKGROUND/AIMS/METHODS Since in rat experiments, activation of progenitor cells is seen in conditions associated with hepatocyte… Expand
Highly Cited
1992
Highly Cited
1992
Direct evidence that hepatocyte growth factor is a hepatotrophic factor for liver regeneration and has a potent antihepatitis effect in vivo
Hepatocyte growth factor, a potent mitogen for mature hepatocytes in vitro, seems to function as a hepatotrophic factor for liver… Expand
Highly Cited
1991
Highly Cited
1991
An antibody to neutrophils attenuates alpha-naphthylisothiocyanate-induced liver injury.
alpha-Naphthylisothiocyanate (ANIT) causes cholestasis and injury to bile duct epithelium and hepatic parenchymal cells in rats… Expand
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