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Chemical characterization of pheomelanogenesis starting from dihydroxyphenylalanine or tyrosine and cysteine. Effects of tyrosinase and cysteine concentrations and reaction time.
- Hirofumi Ozeki, S. Ito, K. Wakamatsu, I. Ishiguro
- Chemistry, Medicine
- Biochimica et biophysica acta
- 1 October 1997
Two types of melanin pigment are produced in mammals; the brown-to-black eumelanins and the yellow-to-reddish-brown pheomelanins. The switch from one type of melanin to the other appears to be… Expand
Involvement of the xanthine-xanthine oxidase system and neutrophils in the development of acute gastric mucosal lesions in rats with water immersion restraint stress.
In rats subjected to water immersion restraint (WIR) stress for 1, 3, and 6 h, gastric mucosal lesions developed time-dependently with an increase in lipid peroxide (LPO) levels and a decrease in… Expand
Therapeutic effect of melatonin on carbon tetrachloride‐induced acute liver injury in rats
- Y. Ohta, M. Kongo, E. Sasaki, K. Nishida, I. Ishiguro
- Journal of pineal research
- 1 February 2000
The therapeutic effect of melatonin on acute liver injury was examined in rats intoxicated with carbon tetrachloride (CCl4). Melatonin (10, 50, or 100 mg/kg body weight [BW]) was intraperitoneally… Expand
Contribution of NO synthases to neutrophil infiltration in the gastric mucosal lesions in rats with water immersion restraint stress
A decrease in constitutive NO synthase (cNOS) activity and an increase in inducible NO synthase (iNOS) activity occurred with an increase in myeloperoxidase (MPO) activity, an index of neutrophil… Expand
An association between lipid peroxidation and alpha-naphthylisothiocyanate-induced liver injury in rats.
- M. Kongo, Y. Ohta, K. Nishida, E. Sasaki, N. Harada, I. Ishiguro
- Chemistry, Medicine
- Toxicology letters
- 29 March 1999
An association between lipid peroxidation and alpha-naphthylisothiocyanate (ANIT)-induced liver injury was examined in rats injected once with the toxicant (75 mg/kg body weight). The severity of… Expand
Δ1-pyrroline-5-carboxylate reductase from baker's yeast. Purification, properties and its application in the assays of -Δ1-pyrroline-5-carboxylate and l-ornithine in tissue
Abstract Δ1-pyrroline-5-carboxylate reductase ( l -proline:NAD(P)+ 5-oxidoreductase, EC 18.104.22.168) from Baker's yeast has been purified and characterized. Purification to an apparently homogenous… Expand
Preventive effect of Oren-gedoku-to (Huanglian-Jie-Du-Tang) extract on the development of stress-induced acute gastric mucosal lesions in rats.
- Y. Ohta, T. Kobayashi, K. Nishida, E. Sasaki, I. Ishiguro
- Journal of ethnopharmacology
- 30 November 1999
The preventive effect of Oren-gedoku-to (Huanglian-Jie-Du-Tang) extract (TJ-15), a traditional Chinese herbal medicine for the therapies of gastric ulcers and gastritis, on the development of… Expand
Role of endogenous serotonin and histamine in the pathogenesis of gastric mucosal lesions in unanaesthetised rats with a single treatment of compound 48/80, a mast cell degranulator.
In unanaethetised rats with a single injection of compound 48/80, a mast cell degranulator (0.75 mg kg-1, i.p.), gastric lesions occurred with increased serum serotonin and histamine levels and… Expand
Protective effect of melatonin against α‐naphthylisothiocyanate‐induced liver injury in rats
The protective effect of melatonin against α‐naphthylisothiocyanate (ANIT)‐induced liver injury with cholestasis was examined in rats injected once with the toxicant (75 mg/kg body weight (BW)). In… Expand
Role of catalase in retinal antioxidant defence system: its comparative study among rabbits, guinea pigs, and rats.
- Y. Ohta, T. Yamasaki, T. Niwa, K. Niimi, Y. Majima, I. Ishiguro
- Biology, Medicine
- Ophthalmic research
The role of catalase in the retinal antioxidant defence system was examined in rabbits, guinea pigs, and rats with and without prolonged administration of a diet containing 0.4% 3-aminotriazole… Expand