Skip to search formSkip to main contentSkip to account menu

1,5-dihydroxyisoquinoline

Known as: 1,5-isoquinolinediol 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

IsoquinolinesPoly(ADP-ribose) Polymerase Inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
[Effects of titanium dioxide nanoparticles on fecal metabolome in rats after oral administration for 90 days].
OBJECTIVE To explore the effects and related mechanisms of oral exposure titanium dioxide nanoparticles (TiO2 NPs) for 90 days on… 
2015
2015
Pharmacogenomic analysis indicates potential of 1,5-isoquinolinediol as a universal anti-aging agent for different tissues
The natural aging of multicellular organisms is marked by a progressive decline in the function of cells and tissues. The… 
2014
2014
Reversal of neurobehavioral and neurochemical alterations in STZ-induced diabetic rats by FeTMPyP, a peroxynitrite decomposition catalyst and 1,5-Isoquinolinediol a poly(ADP-ribose) polymerase…
Abstract Objective: In this study, we have evaluated the involvement of nitrosative stress and poly-ADP ribosyl polymerase (PARP… 
2011
2011
A 3-D microfluidic combinatorial cell array
We present the development of a three-dimensional (3-D) combinatorial cell culture array device featured with integrated three… 
2009
2009
Anticataract effect as a predictor of drug efficacy against early diabetes‐induced retinal changes
Purpose To evaluate if anticataract effect predicts drug efficacy against early diabetes-induced retinal changes, using STZ… 
Highly Cited
2005
Highly Cited
2005
Mitochondrial impairment induced by poly(ADP‐ribose) polymerase‐1 activation in cortical neurons after oxygen and glucose deprivation
Neuronal cells injured by ischemia and reperfusion to a certain extent are committed to death in necrotic or apoptotic form… 
2004
2004
Caspase‐1 and poly (ADP‐ribose) polymerase inhibitors may protect against peroxynitrite‐induced neurotoxicity independent of their enzyme inhibitor activity
We investigated the mechanism of 3‐morpholinosyndnomine (SIN‐1) neurotoxicity in nearly pure neuronal cultures. In a simple… 
2003
2003
1,5-isoquinolinediol increases the frequency of gene targeting by homologous recombination in mouse fibroblasts.
Gene targeting is a technique that allows the introduction of predefined alterations into chromosomal DNA. It involves a… 
2003
2003
Activation of Poly(adenosine diphosphate–ribose) Polymerase in Mouse Tumors Treated by Photodynamic Therapy ¶
Poly(adenosine diphosphate–ribose) polymerase (PARP) has recently been characterized as a key regulator of cell death–survival… 
1999
1999
Inhibition of poly(ADP-ribose)polymerase stimulates extrachromosomal homologous recombination in mouse Ltk-fibroblasts.
Poly(ADP-ribose)polymerase (PARP) is an abundant nuclear enzyme activated by DNA breaks. PARP is generally believed to play a… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)