(N)-methanocarba-2MeSADP

Metabotropic P2Y receptors subfamily consists of eight functional mammalian receptors. Specifically, P2Y1, P2Y6 and P2Y11… Expand

During exercise, skeletal muscle produces reactive oxygen species (ROS) via NADPH oxidase (NOX2) while inducing cellular… Expand

Purines induce transient contraction and prolonged relaxation of detrusor muscles. Transient contraction could be due to… Expand

Although previous reports have suggested that P2Y1 receptors (P2Y1Rs) are involved in cutaneous nociceptive signaling, it remains… Expand

Traumatic brain injury (TBI) is the leading cause of death and disability in children and young adults. Neuroprotective agents… Expand

BACKGROUND In the present study, we further characterize the purinergic receptors mediating the inhibitory junction potential… Expand

G protein-coupled receptors, the largest cell surface receptor family, have emerged as critical players in cell death and… Expand

BACKGROUND AND PURPOSE This study was undertaken to compare the analgesic activity of antagonists acting at P2X1, P2X7, and P2Y12… Expand

Stimulation of receptors for either ATP or adenosine leads to physiologic changes in retinal pigment epithelial (RPE) cells that… Expand

In comparison to other classes of cell surface receptors, the medicinal chemistry at P2X (ligand-gated ion channels) and P2Y (G… Expand