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Foxg1 Suppresses Early Cortical Cell Fate
During mammalian cerebral corticogenesis, progenitor cells become progressively restricted in the types of neurons they can produce. The molecular mechanism that determines earlier versus later bornExpand
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Brain Factor-1 Controls the Proliferation and Differentiation of Neocortical Progenitor Cells through Independent Mechanisms
The winged helix gene Brain factor-1 (BF1) has a pleiotropic role in the development of the cerebral hemispheres of the brain. Mice lacking BF1 have defects in the morphogenesis of the structures ofExpand
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The Role of Foxg1 and Dorsal Midline Signaling in the Generation of Cajal-Retzius Subtypes
Cajal-Retzius (CR) cells, the earliest-born neurons in the neocortex, arise from discrete sources within the telencephalon, including the dorsal midline and the pallial–subpallial boundary (PSB). InExpand
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Foxg1 coordinates the switch from nonradially to radially migrating glutamatergic subtypes in the neocortex through spatiotemporal repression.
The specification of neuronal subtypes in the cerebral cortex proceeds in a temporal manner; however, the regulation of the transitions between the sequentially generated subtypes is poorlyExpand
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Pyramidal Neurons Grow Up and Change Their Mind
The precise stereotypic projections of pyramidal neurons within the six-layered cortex of mammals are key in allowing this structure to attain its high level of function. Recent studies have providedExpand
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Switching modes in corticogenesis: mechanisms of neuronal subtype transitions and integration in the cerebral cortex
Information processing in the cerebral cortex requires the activation of diverse neurons across layers and columns, which are established through the coordinated production of distinct neuronalExpand
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Robo1 regulates the migration and laminar distribution of upper-layer pyramidal neurons of the cerebral cortex.
Laminar organization is a key feature of the mammalian cerebral cortex, but the mechanisms by which final positioning and "inside-out" distribution of neurons are determined remain largely unknown.Expand
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Robo1 Modulates Proliferation and Neurogenesis in the Developing Neocortex
The elaborate cytoarchitecture of the mammalian neocortex requires the timely production of its constituent pyramidal neurons and interneurons and their disposition in appropriate layers. NumerousExpand
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Diencephalic progenitors contribute to the posterior septum through rostral migration along the hippocampal axonal pathway
Septal nuclei are telencephalic structures associated with a variety of brain functions as part of the limbic system. The two posterior septal nuclei, the triangular septal nucleus (TS) and the bedExpand
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Building Bridges to the Cortex
Innervation of the neocortex by the thalamus is dependent on the precise coordination of spatial and temporal guidance cues. In this issue of Cell, work by López-Bendito et al.(2006) reveals thatExpand
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