(22R)-22-hydroxycholesterol

Previously we showed L-4F, a novel apolipoprotein A-I (apoA-I) mimetic, improved vasodilation in 2 dissimilar models of vascular… (More)

Fatty acid metabolism is transcriptionally regulated by two reciprocal systems: peroxisome proliferator-activated receptor (PPAR… (More)

The nuclear receptors liver X receptor (LXR) alpha and LXRbeta serve as oxysterol receptors and regulate the expression of genes… (More)

In an attempt to identify transcription factors which activate sterol-regulatory element-binding protein 1c (SREBP-1c… (More)

The current paper describes a line of cultured rat hepatoma cells (McA-RH7777 cells) that mimics the behavior of rat liver by… (More)

The nuclear receptors liver X receptor alpha (LXRalpha) (NR1H3) and LXRbeta (NR1H2) are important regulators of genes involved in… (More)

The cholesterol 7alpha-hydroxylase gene (CYP7A1) plays an important role in regulation of bile acid biosynthesis and cholesterol… (More)

Tangier disease, a condition characterized by low levels of high density lipoprotein and cholesterol accumulation in macrophages… (More)

To identify genes that are transcriptionally activated when human macrophages accumulate excess lipids, we employed the mRNA… (More)

LXRalpha and -beta are nuclear receptors that regulate the metabolism of several important lipids, including cholesterol and bile… (More)