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International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2
This review summarizes current data indicating the extent to which cannabinoid receptor ligands undergo orthosteric or allosteric interactions with non- CB1, non-CB2 established GPCRs, deorphanized receptors such as GPR55, ligand-gated ion channels, transient receptor potential (TRP) channels, and other ion channels or peroxisome proliferator-activated nuclear receptors.
The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina.
Influence of dietary fatty acids on endocannabinoid and N-acylethanolamine levels in rat brain, liver and small intestine.
Dynamic changes of the endogenous cannabinoid and opioid mesocorticolimbic systems during adolescence: THC effects
2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans.
2-oleoyl glycerol (2OG) and other 2-monoacylglycerols formed during fat digestion can activate GPR119 and cause incretin release from the human intestine, and this mechanism is likely to contribute to the known stimulatory effect of dietary fat on incretsin secretion.
N-Acylethanolamines and precursor phospholipids - relation to cell injury.
Anandamide, but not 2‐arachidonoylglycerol, accumulates during in vivo neurodegeneration
Analysis of cannabinoid CB1 receptor mRNA expression and binding capacity revealed that cortical subfields exhibited an up‐regulation of these parameters following mild concussive head trauma and exposure to NMDA receptor blockade, which may suggest that mild to moderate brain injury may trigger elevated endocannabinoid activity via concomitant increase of anandamide levels, but not 2‐AG, andCB1 receptor density.
INTAKE OF MARINE FAT, RICH IN (n-3)-POLYUNSATURATED FATTY ACIDS, MAY INCREASE BIRTHWEIGHT BY PROLONGING GESTATION
Long-term characterization of the diet-induced obese and diet-resistant rat model: a polygenetic rat model mimicking the human obesity syndrome.
The data highlights the usefulness of a polygenetic animal model for screening of compounds affecting food intake, body weight, and glucose homeostasis and underscores the effectiveness of GLP-1 mimetics both as anti-diabetes and anti-obesity agents.
The endocannabinoid system and its relevance for nutrition.
The main features of the ECS are summarized in order to put in better focus current knowledge of the nutritional relevance of endocannabinoid signaling and of its role in obesity, cardiovascular pathologies, and gastrointestinal diseases.