M. Schumacher

Publications23
h-index12
Citations650
Highly Influential Citations6
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Rapid isolation of mouse Leydig cells by centrifugation in Percoll density gradients with complete retention of morphological and biochemical integrity.
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Effects of acute tryptophan depletion on nocturnal melatonin secretion in humans.
TLDR
It is suggested that reduced plasma tryptophan levels, and presumably brain serotonin concentrations, decrease nocturnal melatonin secretion in humans.
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Steroidogenic effect of atrial natriuretic factor in isolated mouse Leydig cells is mediated by cyclic GMP.
TLDR
It is concluded that cyclic GMP acts as a second messenger in atrial-peptide-stimulated steroidogenesis in mouse Leydig cells and results from an insufficient formation of cyclicGMP in these cells.
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Sex steroids do not alter melatonin secretion in the human.
TLDR
It is suggested that circadian melatonin secretion is not significantly modulated by sex steroids, and plasma samples obtained at 4-hourly intervals in a 24 h period suggest this.
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Desensitization of the cAMP system in mouse Leydig cells by hCG, cholera toxin, dibutyryl cAMP and cAMP: localization of the ‘lesion’ to the guanine nucleotide regulatory protein-adenylate cyclase…
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Guanine nucleotide mediated desensitization of adenylate cyclase in cell free preparations from a Leydig cell tumour.
TLDR
It is proposed that in similarity with the ovary, desensitization of Leydig tumour cell plasma membrane adenylate cyclase may involve a GTP-mediated phosphorylation step.
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Inhibition of hCG‐stimulated adenylate cyclase in purified mouse Leydig cells by the phorbol ester PMA
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Protein-bound cAMP, total cAMP, and protein kinase activation in isolated bovine thyrocytes.
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Maximal steroidogenic capacity of mouse leydig cells
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Desensitization of tumour Leydig cells by lutropin: evidence for uncoupling of the lutropin receptor from the guanine nucleotide-binding protein.
TLDR
The present evidence obtained from studies both with intact cells and with isolated plasma membranes indicates that the initial lutropin-induced desensitization of the rat Leydig tumour cell is due to a lesion in the hormone-receptor coupling to the guanine nucleotide regulatory protein.
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