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Effects of acute tryptophan depletion on nocturnal melatonin secretion in humans.
TLDR
It is suggested that reduced plasma tryptophan levels, and presumably brain serotonin concentrations, decrease nocturnal melatonin secretion in humans.
Steroidogenic effect of atrial natriuretic factor in isolated mouse Leydig cells is mediated by cyclic GMP.
TLDR
It is concluded that cyclic GMP acts as a second messenger in atrial-peptide-stimulated steroidogenesis in mouse Leydig cells and results from an insufficient formation of cyclicGMP in these cells.
Sex steroids do not alter melatonin secretion in the human.
TLDR
It is suggested that circadian melatonin secretion is not significantly modulated by sex steroids, and plasma samples obtained at 4-hourly intervals in a 24 h period suggest this.
Guanine nucleotide mediated desensitization of adenylate cyclase in cell free preparations from a Leydig cell tumour.
TLDR
It is proposed that in similarity with the ovary, desensitization of Leydig tumour cell plasma membrane adenylate cyclase may involve a GTP-mediated phosphorylation step.
Desensitization of tumour Leydig cells by lutropin: evidence for uncoupling of the lutropin receptor from the guanine nucleotide-binding protein.
TLDR
The present evidence obtained from studies both with intact cells and with isolated plasma membranes indicates that the initial lutropin-induced desensitization of the rat Leydig tumour cell is due to a lesion in the hormone-receptor coupling to the guanine nucleotide regulatory protein.
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