• Corpus ID: 1254752

T cell-mediated, IFN-gamma-facilitated rejection of murine B16 melanomas.

@article{Bohm1998TCI,
  title={T cell-mediated, IFN-gamma-facilitated rejection of murine B16 melanomas.},
  author={Waltraud Böhm and Stefan Thoma and Frank Leithäuser and Peter M{\o}ller and Reinhold Schirmbeck and J{\"o}rg Reimann},
  journal={Journal of immunology},
  year={1998},
  volume={161 2},
  pages={
          897-908
        },
  url={https://api.semanticscholar.org/CorpusID:1254752}
}
The data suggest that CTL-derived IFN-gamma enhances an intrinsic suicide mechanism of these tumor cells in addition to facilitating lytic interactions of effectors with tumor targets.
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59 References

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Immunization with soluble hepatitis B virus surface protein elicits murine H-2 class I-restricted CD8+ cytotoxic T lymphocyte responses in vivo.

Injections of various dosages of a S protein-derived, immunogenic, synthetic peptide into BALB/c mice by various routes did not prime CTL and these findings are of relevance for the design of synthetic subunit vaccines for which specific stimulation of CD8+ T effector functions is desired.

Antitumor effect of locally produced CD95 ligand

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It is concluded that an IL- 2 signalling system is present in murine B16F10 melanoma cells and that IL-2 favors B16f10 cell proliferation, suggesting a role for this cytokine in the tumoral activity of these cells.
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