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  • Willem W. Overwijk, Marc Robert Theoret, +15 authors Nicholas P. Restifo
  • Medicine, Biology
  • The Journal of experimental medicine
  • 2003 (First Publication: 18 August 2003)
  • Many tumor-associated antigens are derived from nonmutated “self” proteins. T cells infiltrating tumor deposits recognize self-antigens presented by tumor cells and can be expanded in vivo withExpand
  • Luca Gattinoni, Christopher A. Klebanoff, +7 authors Nicholas P. Restifo
  • Medicine, Biology
  • The Journal of clinical investigation
  • 2005 (First Publication: 1 June 2005)
  • T cell differentiation is a progressive process characterized by phenotypic and functional changes. By transferring tumor-specific CD8+ T cells into tumor-bearing mice at various stages ofExpand
  • Luca Gattinoni, Steven Eric Finkelstein, +10 authors Nicholas P. Restifo
  • Medicine, Biology
  • The Journal of experimental medicine
  • 2005 (First Publication: 3 October 2005)
  • Depletion of immune elements before adoptive cell transfer (ACT) can dramatically improve the antitumor efficacy of transferred CD8+ T cells, but the specific mechanisms that contribute to thisExpand
  • Chrystal M. Paulos, Claudia Wrzesinski, +11 authors Nicholas P. Restifo
  • Biology, Medicine
  • The Journal of clinical investigation
  • 2007 (First Publication: 1 August 2007)
  • Lymphodepletion with total body irradiation (TBI) increases the efficacy of adoptively transferred tumor-specific CD8(+) T cells by depleting inhibitory lymphocytes and increasing homeostaticExpand