Longitudinal predictors of airway responsiveness to distilled water: the role of atopy and maternal smoke exposure.

@article{Studnicka1998LongitudinalPO,
  title={Longitudinal predictors of airway responsiveness to distilled water: the role of atopy and maternal smoke exposure.},
  author={Michael Studnicka and B Roithner and C. Gartner and Scott T. Weiss and M G Neumann and Thomas Frischer},
  journal={The European respiratory journal},
  year={1998},
  volume={12 1},
  pages={
          75-81
        },
  url={https://api.semanticscholar.org/CorpusID:18751156}
}
Atopy and exposure to maternal smoking can predict longitudinal change in childhood airway responsiveness, and was observed primarily in nonatopic children.
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11 Citations
Background Citations
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Results Citations
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11 Citations

Histamine challenges discriminate between symptomatic and asymptomatic children. MAS-Study Group. Multicentre Allergy Study.

The results indicate that a very low cut-off provocative concentration causing a 20% fall in forced expired volume in one second (<1.0 mg x mL(-1)) defines airway hyperresponsiveness in children aged 7 yrs using the reservoir method.

The effect of ozone on inner-city children with asthma: identification of susceptible subgroups.

It is concluded that among an asthmatic cohort, children who had had an LBW or a premature birth showed the greatest responses to ozone.

Pulmonary functions in atopic and nonatopic asthmatic children.

RUNX transcription factors: association with pediatric asthma and modulated by maternal smoking.

IUS exposure-altered expression of RUNX transcription factors increases the risk of asthma in children with IUS exposure, and a murine IUS model showed that the effects of developmental cigarette smoke exposure persisted for at least 2 wk after birth.

Involuntary smoking and asthma.

Protecting children and others from ETS will require combined and ongoing efforts of the medical and public health establishments, in concert with legislation mandating tobacco-free public places and with ETS-related media campaigns.

Involuntary smoking is the third leading preventable cause of death, and among children it causes lower respiratory infec-

Community norms may need to shift further in favor of protecting children and others from ETS before minimal interventions can be successful, and combined and ongoing efforts of the medical and public health establishments are needed.

Recurrent wheezing in infants and young children and bronchial hyperresponsiveness

If exaggerated BHR in recurrent wheezing children without asthma has the same inherent disadvantage as it does in asthmatic children, additional studies looking directly at this issue in a longitudinal fashion need to be designed.

Tobacco smoke exposure and tracking of lung function into adult life.

Reducing secondhand smoke exposure among children and adolescents: emerging issues for intervening with medically at-risk youth.

Ongoing intervention research and identification of strategies to capitalize on opportunities for providing effective SHS counseling in primary care and specialty clinics will be critical for effective tobacco control among medically at-risk children.

Airway inflammation in school-aged children with asthma

The literature review concludes that asthma and Tobacco smoke exposure in children is a major risk factor for asthma in children and should be considered as a public health concern.

28 References

Longitudinal variability in airway responsiveness in a population-based sample of children and young adults. Intrinsic and extrinsic contributing factors.

Airway hyperresponsiveness was demonstrated consistently over all surveys in only six of 49 (12%) subjects who had ever demonstrated a "positive" airway response, and significant predictors of airwayhyperresponsiveness were wheeze symptoms, hay fever, and a chest illness requiring bed rest.

The influence of a family history of asthma and parental smoking on airway responsiveness in early infancy.

This study indicates thatAirway responsiveness can be present early in life and suggests that a family history of asthma or parental smoking contributes to elevated levels of airway responsiveness at an early age.

A longitudinal evaluation of bronchial responsiveness to methacholine in children: role of baseline lung function, gender, and change in atopic status.

It is concluded that bronchial responsiveness to methacholine declines from childhood to adolescence, paralleling the increase in lung function during this period; the decline is less pronounced in females.

Determinants of airway response to challenge with distilled water in a population sample of children aged 7 to 10 years old.

It is concluded that a significant relationship between airway response to distilled water, asthma and symptoms suggestive for asthma exists for a childhood population sample.

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Regression analyses demonstrated that lower levels of VFRC were associated with an increased frequency of LRI, especially in female infants, and differences in lung function were greatest infemale infants whose mothers did not smoke during pregnancy.

Seasonal and allergenic predictors of bronchial responsiveness to distilled water.

Increased bronchial responsiveness in spring among children allergic to grass pollen is demonstrated, and the change in responsiveness between seasons was most significantly predicted by allergy to seasonal grass pollen.

Prevalence and predictors of bronchial hyperresponsiveness in children aged 7‐16 years

It is concluded that BH is severest in children with asthma, independent of elevated IgE or positive skin prick test, or elevation of IgE in children without atopic symptoms.

On adjusting measurements of airway responsiveness for lung size and airway caliber.

FVC and FEV1/FVC have a small but significant effect on the measurement of airway responsiveness and that more precise measurements of the prevalence of AHR can be obtained by standardization for these parameters.

Passive smoking as a determinant of bronchial responsiveness in children.

It is suggested that the effect of parental smoking on children's bronchial responsiveness is detectable when the conditions for a higher exposure level at home are met; females seem to be more susceptible.

Relation of the course of bronchial responsiveness from age 9 to age 15 to allergy.

Both the overall tendency to BHR and the tendency to retain BHR were closely related to high serum IgE levels and to positive allergy skin tests, which appeared to be important determinants of the frequency of wheeze and the degree of impairment of lung function at the end of follow-up.