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Changes in the normal maximal expiratory flow-volume curve with growth and aging.
Improved prediction equations for each sex by age group for 5 spirometric and flow-volume variables are derived and "Normal" limits are proposed that take into consideration the between-subject variability and non-Gaussian distribution of the various measurements. Expand
Association of asthma with serum IgE levels and skin-test reactivity to allergens.
It is concluded that asthma is almost always associated with some type of IgE-related reaction and therefore has an allergic basis, although not all the allergic stimuli that cause asthma appear to have been included in the battery of common aeroallergens the authors used to assess atopic status. Expand
Effects of Smoking Intervention and the Use of an Inhaled Anticholinergic Bronchodilator on the Rate of Decline of FEV1: The Lung Health Study
An aggressive smoking intervention program significantly reduces the age-related decline in FEV 1 in middle-aged smokers with mild airways obstruction and use of an inhaled anticholinergic bronchodilator results in a relatively small improvement inFEV 1 that appears to be reversed after the drug is discontinued. Expand
Relation between airway responsiveness and serum IgE in children with asthma and in apparently normal children.
Even in children who have been asymptomatic throughout their lives and have no history of atopic disease, airway hyperresponsiveness appears to be closely linked to an allergic diathesis, as reflected by the serum total IgE level. Expand
The course and prognosis of different forms of chronic airways obstruction in a sample from the general population.
Examination of the course and prognosis in subjects selected from the general population who had chronic airflow obstruction at the time of their enrollment in a longitudinal epidemiologic study found better control of the progression of asthmatic bronchitis with therapy may explain its more favorable prognosis. Expand
Quantitative relationships between cigarette smoking and ventilatory function.
Allergy skin test reactivity in young to middle-aged adults showed a significant additive effect to pack-years as a determinant of forced expiratory flow toward the end of the forced vital capacity, but the effect was noted only among present smokers. Expand
Epidemiology of chronic obstructive pulmonary disease.
Morbidity and mortality rates for chronic obstructive pulmonary disease (COPD) have been increasing over time. Epidemiologic investigators of COPD have been exploring the reasons for these increasesExpand
Decline of height with age in adults in a general population sample: estimating maximum height and distinguishing birth cohort effects from actual loss of stature with aging.
The decline in stature with age among adults is well documented. Although part of this represents a birth cohort effect, actual height declines among older individuals are known to contribute to theExpand
Cryptogenic fibrosing alveolitis: clinical features and their influence on survival
A retrospective analysis of 220 cases fulfilling criteria for cryptogenic fibrosing alveolitis (CFA) attending the Brompton Hospital between 1955 and 1973 has been carried out and patients have beenExpand