Ability of Mn2+ to Permeate the Eye and Availability of Manganese-enhanced Magnetic Resonance Imaging for Visual Pathway Imaging via Topical Administration
@article{Chen2016AbilityOM, title={Ability of Mn2+ to Permeate the Eye and Availability of Manganese-enhanced Magnetic Resonance Imaging for Visual Pathway Imaging via Topical Administration}, author={Yao Chen and Chunyan Shi and Y. Li and Yuntao Hu and Hong-bin Han and Xiaodong Sun and Satyajeet Sudhir Salvi and Zhi-zhong Ma}, journal={Chinese Medical Journal}, year={2016}, volume={129}, pages={1822 - 1829}, url={https://api.semanticscholar.org/CorpusID:37612905} }
The corneal epithelium is a barrier to Mn2+, and the iris and lens septum might be another intraocular barrier to the permeation of Mn2+.
3 Citations
Manganese-enhanced magnetic resonance imaging in the whole visual pathway: chemical identification and neurotoxic changes
- 2019
Medicine, Chemistry
This study indicated that MEMRI with TSMIP after injection of 200 nmol MnCl2 can best show the entire and 3D visual pathway in the rat with less neurotoxic changes, and chemical identification is useful for the confirmation of the specificity of MEMRI.
Applications of Manganese-Enhanced Magnetic Resonance Imaging in Ophthalmology and Visual Neuroscience
- 2019
Medicine, Physics
Four major domains of scientific inquiry where MEMRI can be put to imperative use — deciphering neuroarchitecture, tracing neuronal tracts, detecting neuronal activity, and identifying or differentiating glial activity are presented.
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Medicine
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Increase the time intervals of repeated Mn(2+) topical administration reduced the adverse effects caused by MEMRI, and all mice exhibited consistent enhancements along the visual system following repeated MEMRI.
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Medicine
Intravitreal MnCl2injection provides more reproducible results with less adverse side‐effects than topical loading in MEMRI measurements and to assess the integrity of retinas and optic nerves.
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Environmental Science, Medicine
It can be concluded that intravitreal injection of MnCl2 induces retinal cell damage that appears to start from 25 mm, and the concentration of Mncl2 should not exceed 25 mm through intrav itreal injection for visual pathway MEMRI in the rat.
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This review will describe the methodologies and applications of MEMRI in the following areas: monitoring brain activity in animal models, in vivo neuronal tract tracing and using MEMRI to assess in vivo axonal transport rates.
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