Skip to search formSkip to main contentSkip to account menu

Distribution of the tight junction proteins ZO-1, occludin, and claudin-4, -8, and -12 in bladder epithelium.

Results indicate that claudin-4, -8, and -12 are expressed in umbrella cells, where they may impart the high-resistance phenotype associated with this cell type, and that in some instances tight junction proteins are also associated at the sites of cell contact of the underlying cell layers, perhaps playing some role in cell-cell adhesion.
PubMed (opens in a new tab)

Pannexin 1 channels mediate the release of ATP into the lumen of the rat urinary bladder

The data indicate a role for pannexin‐mediated luminal ATP release in both the physiological and pathophysiological control of micturition and suggest that urothelialpannexin may be a viable target for the treatment of overactive bladder disorders.
Wiley (opens in a new tab)

Expression of functional nicotinic acetylcholine receptors in rat urinary bladder epithelial cells.

Results are the first indication that stimulation of nonneuronal nicotinic receptors in the bladder can affect micturition.
PubMed (opens in a new tab)

Lysosomal alkalinization, lipid oxidation, and reduced phagosome clearance triggered by activation of the P2X7 receptor

It is demonstrated that stimulation of the P2X7 receptor for ATP alkalinizes lysosomes in cultured human retinal pigmented epithelial (RPE) cells and impairs lysOSomal function, suggesting a possible role for overstimulation in diseases of accumulation.
Wiley (opens in a new tab)

Non-neuronal acetylcholine and urinary bladder urothelium.

Observations indicate that acetylcholine release from urothelial cells is mediated by different mechanisms than those such as vesicular storage and exocytosis that underlie the release of neurotransmitters from nerves.
PubMed (opens in a new tab)

Neurons respond directly to mechanical deformation with pannexin‐mediated ATP release and autostimulation of P2X7 receptors

Stretch‐dependent release of ATP through neuronal pannexins, combined with the autostimulation of the P2X7 receptors, provides a new pathway by which neuronal activity and health can be altered by mechanical strain independently of glial activity.
Wiley (opens in a new tab)

Expression and function of bradykinin B1 and B2 receptors in normal and inflamed rat urinary bladder urothelium

Urothelial expression of bradykinin receptors is plastic and is altered by pathology, as demonstrated in rats treated with CYP‐induced cystitis.
Wiley (opens in a new tab)

The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain

Mechanical trauma to the retina primed NLRP3 inflammasome components, but only if there was ATP release through pannexin hemichannels, and autostimulation of the P2X7 receptor.
PubMed (opens in a new tab)

Functional roles for PIEZO1 and PIEZO2 in urothelial mechanotransduction and lower urinary tract interoception

The studies reveal that the urothelium functions in a sex- and circadian rhythm–dependent manner to link Urothelial PIEZO1/2 channel–driven mechanotransduction to normal voiding function and behavior, and in the absence of these signals, bladder dysfunction ensues.
PDF (opens in a new tab)

Heterogeneity of muscarinic receptor-mediated Ca 2 (cid:1) responses in cultured urothelial cells from rat

Support is provided for the proposed role of Urothelial mAChRs in bladder function and for interactions between urothelium (via urothe-lium-derived factors), efferent and afferent nerves, that together can trigger release of ATP.
...
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)