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zardaverine

Known as: 6-(4-difluoromethoxy-3-methoxyphenyl)-3(2H)pyridazinone 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (3)

Bronchodilator AgentsPhosphodiesterase InhibitorsPyridazines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Multi-omics “upstream analysis” of regulatory genomic regions helps identifying targets against methotrexate resistance of colon cancer
Review
2015
Review
2015
Pyridazinone: an important element of pharmacophore possessing broad spectrum of activity
In the last few years, the pyridazine derivatives have been found to exhibit a wide range of pharmacological activities. A large… 
Highly Cited
2004
Highly Cited
2004
Sertoli cell junctional proteins as early targets for different classes of reproductive toxicants.
Review
1995
Review
1995
PDE isoenzymes as targets for anti-asthma drugs.
Phophodiesterase (PDE) isoenzyme profiles of human cell preparations and tissues have been analysed by a semiquantitative method… 
Highly Cited
1994
Highly Cited
1994
Identification of PDE isozymes in human pulmonary artery and effect of selective PDE inhibitors.
The effects of the nonselective phosphodiesterase (PDE) inhibitor 3-isobutyl-1-methylxanthine (IBMX) and the selective PDE… 
1993
1993
Protection by phosphodiesterase inhibitors against endotoxin-induced liver injury in galactosamine-sensitized mice.
Highly Cited
1993
Highly Cited
1993
Role of phosphodiesterases in the regulation of endothelial permeability in vitro.
Neutrophil-derived hydrogen peroxide (H2O2) is believed to play an important role in the pathogenesis of vascular injury and… 
Highly Cited
1993
Highly Cited
1993
Phosphodiesterase isozymes modulating inherent tone in human airways: identification and characterization.
The effects of the nonselective phosphodiesterase (PDE)-inhibitor 3-isobutyl-1-methylxanthine (IBMX) and the selective PDE… 
Highly Cited
1992
Highly Cited
1992
Bronchodilatory effect of inhaled zardaverine, a phosphodiesterase III and IV inhibitor, in patients with asthma.
Zardaverine is a newly developed selective phosphodiesterase III and IV inhibitor. This study investigates the bronchodilatory… 
Review
1991
Review
1991
Zardaverine: a cyclic AMP specific PDE III/IV inhibitor.
Zardaverine is shown to inhibit selectively two out of five isoenzyme classes of phosphodiesterases, namely PDE III from human… 
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