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zaprinast

Known as: 2-(2-propoxyphenyl)-8-azapurin-6-one, 2-o-propoxyphenyl-8-azapurine-6-one 
 
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
We found that zaprinast, a well‐known cyclic guanosine monophosphate‐specific phosphodiesterase inhibitor, acted as an agonist… Expand
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Highly Cited
2000
Highly Cited
2000
We report here the cloning, expression, and characterization of human PDE11A1, a member of a distinct cyclic nucleotide… Expand
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Highly Cited
2000
Highly Cited
2000
In addition to its cGMP-selective catalytic site, cGMP-binding cGMP-specific phosphodiesterase (PDE5) contains two allosteric… Expand
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Review
1999
Review
1999
  • T. Dousa
  • Kidney international
  • 1999
  • Corpus ID: 36556169
Investigations of recent years revealed that isozymes of cyclic-3', 5'-nucleotide phosphodiesterase (PDE) are a critically… Expand
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Highly Cited
1998
Highly Cited
1998
PURPOSE Sildenafil, an inhibitor of cGMP-specific phosphodiesterase 5 (PDE5), is currently undergoing evaluation as an oral… Expand
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Highly Cited
1998
Highly Cited
1998
We have cloned and characterized the first human isozyme in a new family of cyclic nucleotide phosphodiesterases, PDE9A. By… Expand
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Highly Cited
1997
Highly Cited
1997
The effects of 7-nitroindazole, a putative selective inhibitor of neuronal nitric oxide (NO) synthase and zaprinast, a cGMP… Expand
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Highly Cited
1996
Highly Cited
1996
BACKGROUND Cardiac endothelium releases a number of factors that may modulate performance of underlying cardiac muscle. Nitric… Expand
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Highly Cited
1995
Highly Cited
1995
1. Nitric oxide (NO) relaxes vascular smooth muscle (VSM) by mechanisms which are not fully understood. One possibility is that… Expand
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Highly Cited
1995
Highly Cited
1995
We investigated the effect of zaprinast (M&B 22948), a specific cGMP phosphodiesterase inhibitor, on pulmonary arteries isolated… Expand
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