zaprinast

Known as: 2-(2-propoxyphenyl)-8-azapurin-6-one, 2-o-propoxyphenyl-8-azapurine-6-one 
 
National Institutes of Health

Papers overview

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2014
2014
UNLABELLED Recently identified isocitrate dehydrogenase (IDH) mutations lead to the production of 2-hydroxyglutarate (2HG), an… (More)
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Highly Cited
2006
Highly Cited
2006
We found that zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, acted as an agonist… (More)
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Highly Cited
2005
Highly Cited
2005
5'-Fluorouracil (5-FU), used in the treatment of colon and breast cancers, is converted intracellularly to 5'-fluoro-2… (More)
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Review
2001
Review
2001
Phosphodiesterase 5 terminates the cellular actions of the second messenger molecule cyclic GMP; inhibitors of phosphodiesterase… (More)
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Highly Cited
2000
Highly Cited
2000
Atrial natriuretic peptide (ANP) may function as an endogenous regulator of cardiac hypertrophy, because the natriuretic peptide… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Phosphodiesterase type 5 (PDE5) hydrolyzes cyclic guanosine monophosphate in the lung, thereby modulating nitric oxide… (More)
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1998
1998
BACKGROUND Zaprinast, an inhibitor of guanosine-3',5'-cyclic monophosphate (cGMP)-selective phosphodiesterase, augments smooth… (More)
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1997
1997
The effects of 7-nitroindazole, a putative selective inhibitor of neuronal nitric oxide (NO) synthase and zaprinast, a cGMP… (More)
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1995
1995
Inhaled nitric oxide (NO) has been shown to selectively dilate the pulmonary vasculature. Zaprinast, an inhibitor of guanosine 3… (More)
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1995
1995
We investigated the effect of zaprinast (M&B 22948), a specific cGMP phosphodiesterase inhibitor, on pulmonary arteries isolated… (More)
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