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zaleplon

Known as: 3'-(3-cyanopyrazolo(1,5-alpha)pyrimidin-7-yl)-N-ethylacetanilide, N-(3-(3-cyanopyrazolo(1,5-a)pyrimidin-7-yl)phenyl)-N-ethylacetamide, 3'-(3-Cyanopyrazolo(1,5-a)pyrimidin-7-yl)-N-ethylacetanilide 
A nonbenzodiazepine from the pyrazolopyrimidine class with hypnotic, sedative, anxiolytic, and muscle relaxant properties. Zaleplon interacts with… 
National Institutes of Health

Related topics

Related topics

18 relations

Broader (5)

AcetamidesAnticonvulsantsGABA ModulatorsHypnotics and Sedatives

Narrower (4)

CL 284,846L 846SKP-1041Sonata
CYP3A7 protein, humanCentral Nervous System Depression [PE]Drug AllergyGABA B Agonists [MoA]

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Enhanced Dissolution Efficiency of Zaleplon Solid Dispersions via Modified β-Cyclodextrin Molecular Inclusion Complexes
The focus of the current study is to confirm the potential of chemically modified cyclodextrins (methyl-β-cyclodextrin (MβCD… 
2008
2008
Quantitation of benzodiazepines in whole blood by electron impact-gas chromatography-mass spectrometry.
Benzodiazepines are frequently encountered in forensic toxicology. A literature search was conducted to find a simple method… 
2008
2008
GABAA receptor pharmacology of fluorinated derivatives of the novel sedative-hypnotic pyrazolopyrimidine indiplon.
Review
2007
Review
2007
Update on the safety considerations in the management of insomnia with hypnotics: incorporating modified-release formulations into primary care.
OBJECTIVE From a safety perspective, several issues require assessment when a decision is made to prescribe a sleep medication… 
Highly Cited
2006
Highly Cited
2006
Fast gas chromatography-negative-ion chemical ionization mass spectrometry with microscale volume sample preparation for the determination of benzodiazepines and alpha-hydroxy metabolites, zaleplon…
Fast gas chromatography/negative-ion chemical ionization mass spectrometric (GC/NICI-MS) assay combined with rapid and… 
2004
2004
Direct injection, column switching-liquid chromatographic technique for the estimation of rabeprazole in bioequivalence study.
Highly Cited
2004
Highly Cited
2004
Characterization of the Interaction of Indiplon, a Novel Pyrazolopyrimidine Sedative-Hypnotic, with the GABAA Receptor
Clinically used benzodiazepine and nonbenzodiazepine sedative-hypnotic agents for the treatment of insomnia produce their… 
2003
2003
γ-Hydroxybutyric Acid and Diazepam Antagonize a Rapid Increase in GABAA Receptors α4 Subunit mRNA Abundance Induced by Ethanol Withdrawal in Cerebellar Granule Cells
Both benzodiazepines and γ-hydroxybutyric acid (GHB) are used to treat alcohol withdrawal syndrome. The molecular basis for this… 
2001
2001
Different types of GABAA receptors may mediate the anticonflict and response rate-decreasing effects of zaleplon, zolpidem, and midazolam in squirrel monkeys
Abstract.Rationale: The role of different types of GABAA receptors in mediating anticonflict and response rate-decreasing effects… 
2000
2000
Differentiating benzodiazepine‐ and barbiturate‐like discriminative stimulus effects of lorazepam, diazepam, pentobarbital, imidazenil and zaleplon in two‐ versus three‐lever procedures
Previous studies found that animals trained to discriminate pentobarbital show a relatively inclusive generalization profile… 
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