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Effects of cocaine and related drugs in nonhuman primates. III. Self-administration by squirrel monkeys.
TLDR
The results in conjunction with those of previous studies in squirrel monkeys reveal a close correspondence between the relative potencies of cocaine and related drugs for maintaining i.v. self-administration and for increasing rates of schedule-controlled responding, suggesting that the reinforcing and psychomotor-stimulant effects of the drugs are mediated similarly.
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Modification of cocaine self-administration by buspirone (buspar®): potential involvement of D3 and D4 dopamine receptors.
TLDR
The present research examined the functional effects of buspirone on D3 and D4 receptors and its ability to modify the reinforcing effects of i.v. cocaine in a behaviourally selective manner, supporting the further evaluation of busPirone as a candidate medication for the management of cocaine addiction.
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Discriminative-stimulus effects of clozapine in squirrel monkeys: comparison with conventional and novel antipsychotic drugs
TLDR
It is indicated that some, but not all, structural analogs of clozapine have clozAPine-like discriminative-stimulus effects and that novel antipsychotic drugs which purportedly have clazapine- like clinical efficacy may not produce its interoceptive stimulus effects.
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Some effects of CB1 antagonists with inverse agonist and neutral biochemical properties
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Drug discrimination in methamphetamine-trained monkeys: agonist and antagonist effects of dopaminergic drugs.
  • J. Tidey, J. Bergman
  • Biology, Psychology
    The Journal of pharmacology and experimental…
  • 1 June 1998
TLDR
The view that both dopaminergic D1 and D2 mechanisms mediate the discriminative-stimulus effects of methamphetamine is supported and it is indicated that selected dopamine D1 partial agonists may have antagonist actions at doses that do not produce undesirable effects associated with dopamine receptor blockade.
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Apparent pA2 values of benzodiazepine antagonists and partial agonists in monkeys.
  • C. Paronis, J. Bergman
  • Biology, Psychology
    The Journal of pharmacology and experimental…
  • 1 September 1999
TLDR
The results indicate that in vivo pA(2) values may be determined for benzodiazepine-site ligands, e.
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Effects of dopamine D(1-like) and D(2-like) agonists in rats that self-administer cocaine.
TLDR
D(2) receptor-related neuronal mechanisms may be especially important in mediating the abuse-related effects of cocaine and have prominent reinforcing effects and enhance the effects of self- Administered cocaine in rats with extensive cocaine self-administration experience.
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Receptor affinities of dopamine D1 receptor-selective novel phenylbenzazepines.
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Drug Discrimination in Methamphetamine-Trained Rats: Effects of Cholinergic Nicotinic Compounds
  • R. Desai, J. Bergman
  • Biology, Psychology
    Journal of Pharmacology and Experimental…
  • 1 December 2010
TLDR
Results provide further evidence that nicotinic mechanisms may be useful neurochemical targets for the development of therapeutics for the management of monoaminergic stimulant abuse and addiction.
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Effects of Dopamine D1 Ligands on Eye Blinking in Monkeys: Efficacy, Antagonism, and D1/D2 Interactions
TLDR
Eye blink rate appears to be a robust behavioral measure that can be used to measure changes in dopaminergic D1 signaling and as a functional assay of agonist efficacy at dopamine D1 receptors.
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