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Effective electroconvulsive therapy reverses glutamate/glutamine deficit in the left anterior cingulum of unipolar depressed patients
TLDR
Severe depression seems to be associated with a Glx deficit and increasing Glx may be an important mechanism of ECT action, and in ECT responders, in contrast to non-responders, Glx levels normalized and then did not differ statistically from controls. Expand
Metabolic changes within the left dorsolateral prefrontal cortex occurring with electroconvulsive therapy in patients with treatment resistant unipolar depression
TLDR
The results indicate that major depressive disorder is accompanied by state-dependent metabolic alterations, especially in glutamate/glutamine metabolism, which can be reversed by successful ECT. Expand
Neurotrophic Effects of Electroconvulsive Therapy: A Proton Magnetic Resonance Study of the Left Amygdalar Region in Patients with Treatment-Resistant Depression
TLDR
A preliminary finding of increased NAA concentrations after successful ECT may indicate a probable neurotrophic effect of ECT, which is reported to be important in precipitating clinical depression. Expand
S100B and response to treatment in major depression: a pilot study
TLDR
The results suggest that neuroprotective functions of S100B counterbalance neurodegenerative mechanisms that are involved in the pathophysiology of major depression and in the response to antidepressant treatment. Expand
Possible association of the short allele of the serotonin transporter promoter gene polymorphism (5-HTTLPR) with violent suicide
TLDR
A highly significant increased frequency of suicide victims being carriers of one or two short alleles is found, which suggests that a genetically altered protein function within the serotonergic pathway might be involved in suicidality, independently from the clinical diagnosis. Expand
Acute mania is accompanied by elevated glutamate/glutamine levels within the left dorsolateral prefrontal cortex
TLDR
The results indicate that the prefrontal cortical glutamatergic system is involved in the pathophysiology of acute mania, which may have implications for the treatment of mania. Expand
Studies on a German (Münster) version of the temperament auto-questionnaire TEMPS-A: construction and validation of the briefTEMPS-M.
TLDR
A brief German version of the TEMPS-A auto-questionnaire was constructed, suitable for both clinical and general medical and neurobiological research, as well as in studies on temperament features in selected populations, e.g., allowing comparisons between regions or different (German-speaking) countries. Expand
Carbohydrate-deficient transferrin and alcohol dependency: variation in response to alcohol intake among different groups of patients.
TLDR
It is concluded that CDT and GT show variant responses to alcohol consumption in different groups of patients, and the level of the two markers are related to sex, age, and alcohol consumption. Expand
Bipolar disorder in adults with Asperger׳s Syndrome: a systematic review.
TLDR
BD in AS patients is frequent, usually it onsets during adolescence and is often characterized by atypical presentation, making its correct identification particularly difficult, and a correct diagnosis of BD in AS individuals has relevant implications on the choice of adequate psychopharmacological, psycho-social and rehabilitative treatments. Expand
Association of short-term response to haloperidol treatment with a polymorphism in the dopamine D(2) receptor gene.
TLDR
The hypothesis that genetic variations in the DRD2 gene may influence the individual response to antipsychotics is supported. Expand
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