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zabiciprilat

Known as: carboxy-1-phenyl-3-propylamino-2-propionyl-2-aza-2-bicyclo(2.2.2)octane-3-carboxylic acid, zabiciprilate 
A non-thiol angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Zabiciprilat competitively binds to and inhibits ACE… 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Bridged Bicyclo Compounds, Heterocyclic

Papers overview

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1998
1998
Pharmacokinetic-pharmacodynamic model relating zabiciprilat plasma concentrations to brachial and femoral haemodynamic effects in normotensive volunteers.
AIMS To investigate, in healthy volunteers, the relationships between the plasma concentrations (C, ng ml(-1)) of zabiciprilat… 
1993
1993
Enzyme Immunoassays for a New Angiotensin‐Converting Enzyme Inhibitor, Zabicipril, and Its Active Metabolite in Human Plasma: Application to Pharmacokinetic Studies
Zabicipril (S 9650) is a new angiotensin-converting enzyme inhibitor whose hydrolysis in vivo produces the pharmacologically… 
1992
1992
Comparison of angiotensin-converting enzyme inhibitors in the rat in perfused hindlimbs and in vivo.
1992
1992
Radioimmunoassays for a new angiotensin-converting enzyme inhibitor, zabicipril, and its active metabolite, zabiciprilat, in human plasma.
Zabicipril (Z), a new angiotensin-converting-enzyme inhibitor under development, is a prodrug that has to be deesterified in vivo… 
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