yatakemycin
National Institutes of Health
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CC-1065 is the first characterized member of a family of naturally occurring antibiotics including yatakemycin and duocarmycins…
GyrI-like proteins are widely distributed in prokaryotes and eukaryotes, and recognized as small-molecule binding proteins. Here…
A rocky planet close in size to Earth has been discovered in the cosmic vicinity of our Sun. The small size and proximity of the…
Total syntheses of yatakemycin, PDE-II, dictyodendrins, and heptaphylline are described. This article focuses on the formation of…
Resistance is (not) futile: The yatakemycin biosynthetic gene cluster involves the ytkR2 gene, which encodes a protein with…
DNA-binding small molecules are an important source of anticancer therapeutics that display a diverse array of mechanisms of…
A systematic examination of the impact of the yatakemycin left and right subunits and their substituents is detailed along with a…
Molecular structure and conformational preferences of yatakemycin, a novel and exceptionally potent antitumor agent, have been…
Abstract(+)-Yatakemycin (1, Fig. 1) and (+)-duocarmycin SA (2) are exceptionally potent, naturally occurring antitumor agents…