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A Cell-Targeted Non-Cytotoxic Fluorescent Nanogel Thermometer Created with an Imidazolium-Containing Cationic Radical Initiator.
This cationic fluorescent nanogel thermometer showed an excellent ability to enter live mammalian cells in a short incubation period, a high sensitivity to temperature variations in live cells, and remarkable non-cytotoxicity, which permitted ordinary cell proliferation and even differentiation of primary cultured cells.
Total synthesis of (+)-yatakemycin.
A convergent total synthesis of (+)-yatakemycin was accomplished in a 20-step sequence in an overall yield of 13% using the regioselective ring opening of (S)-epichlorohydrin with 2,6-dibromophenyllithium species.
Synthesis of secondary arylamines through copper-mediated intermolecular aryl amination.
A mild intermolecular copper-mediated amination of aryl iodides has been developed and its synthetic applications include a synthetic protocol for unsymmetrical N,N'-dialkylated phenylenediamines and both a stepwise and a general synthetic method for N-aryl secondary amines via Ns-anilides.
A mild inter- and intramolecular amination of aryl halides with a combination of CuI and CsOAc
Copper-mediated aromatic amination reaction and its application to the total synthesis of natural products.
Herein, we review copper-mediated aromatic amination reactions including the classical Ullmann coupling and the recently developed mild aryl amination with an effective ligand as well as the C-H…
Synthesis of substituted indoline and carbazole by benzyne-mediated cyclization-functionalization.
A benzyne-mediated synthesis of substituted indolines and carbazoles was developed and applied to a concise five-pot total synthesis of heptaphylline.
Total synthesis of dictyodendrin A and B.
- K. Okano, H. Fujiwara, Toshiharu Noji, T. Fukuyama, H. Tokuyama
- Chemistry, BiologyAngewandte Chemie
- 9 August 2010
The first total synthesis of dictyodendrins A and B is reported which features a hitherto unprecedented benzyne-mediated one-pot cyclization/cross-coupling sequence.
Revisiting of Benzophenone Ketyl Still: Use of a Sodium Dispersion for the Preparation of Anhydrous Solvents
A facile generation of organic solvents of anhydrous grade can be performed by distillation from sodium–benzophenone ketyl, which is prepared from commercial sodium dispersion and benzophenone. The…
A concise total synthesis of (−)-indolactam V
Total Synthesis of (-)-Histrionicotoxin through a Stereoselective Radical Translocation-Cyclization Reaction.
The 1-azaspiro[5.5]undecane skeleton was constructed diastereoselectively by a radical translocation-cyclization reaction involving a chiral cyclic acetal; the use of tris(trimethylsilyl)silane was crucial for the high diasterenoselectivity.