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xanomeline

Known as: (3-O-hexyloxy)-TZTP, 3-(3-O-hexyl-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-methylpyridine 
National Institutes of Health

Related topics

Related topics

7 relations

Narrower (2)

LY 246708xanomeline tartrate

Broader (5)

Muscarinic AgonistsParasympathomimetic AgentsPsychotropic DrugsPyridines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Role of Kv7.2/Kv7.3 and M1 muscarinic receptors in the regulation of neuronal excitability in hiPSC-derived neurons.
2011
2011
Behavioral effects of N-desmethylclozapine on locomotor activity and sensorimotor gating function in mice—Possible involvement of muscarinic receptors
2007
2007
Wash-Resistantly Bound Xanomeline Inhibits Acetylcholine Release by Persistent Activation of Presynaptic M2 and M4 Muscarinic Receptors in Rat Brain
We studied the effects of 3-[3-hexyloxy-1,2,5-thiadiazo-4-yl]-1,2,5,6-tetrahydro-1-methylpyridine (xanomeline) wash-resistant… 
2003
2003
Role of muscarinic receptors in the activation of the ventral subiculum and the consequences for dopamine release in the nucleus accumbens.
2000
2000
Design and development of selective muscarinic agonists for the treatment of Alzheimer's disease: characterization of tetrahydropyrimidine derivatives and development of new approaches for improved…
1999
1999
In vitro characterisation of the muscarinic receptor partial agonist, sabcomeline, in rat cortical and heart membranes.
1998
1998
Identification of side chains on 1,2,5-thiadiazole-azacycles optimal for muscarinic m1 receptor activation.
1997
1997
Effects of central muscarinic-1 receptor stimulation on blood pressure regulation.
Stimulation of central nervous system muscarinic-1 (M1) receptors in animals increases blood pressure, heart rate, and… 
1996
1996
PET study of the M1-agonists [11C]xanomeline and [11C]butylthio-TZTP in monkey and man.
Xanomeline, a substituted TZTP, is a new M1 selective muscarinic agonist in clinical trials for Alzheimer's disease. The brain… 
1994
1994
Determination of xanomeline in human plasma by ion-spray tandem mass spectrometry.
Xanomeline is a muscarinic receptor agonist currently in phase II clinical trials for the treatment of Alzheimer's disease. A… 
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