xanomeline

Known as: (3-O-hexyloxy)-TZTP, 3-(3-O-hexyl-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-methylpyridine 
 
National Institutes of Health

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Highly Cited
2008
Highly Cited
2008
OBJECTIVE There are significant unmet needs in the treatment of schizophrenia, especially for the treatment of cognitive… (More)
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2003
2003
Xanomeline is a muscarinic M1/M4 preferring receptor agonist with little or no affinity for dopamine receptors. The compound… (More)
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Highly Cited
2003
Highly Cited
2003
The molecular and neuronal substrates conferring on clozapine its unique and superior efficacy in the treatment of schizophrenia… (More)
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2002
2002
Patients with mild-to-moderate Alzheimer disease received transdermal xanomeline, an M1-selective cholinergic agonist, or placebo… (More)
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2001
2001
The muscarinic receptor agonist xanomeline was examined and compared with the antipsychotics clozapine and/or haloperidol in the… (More)
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Highly Cited
2000
Highly Cited
2000
Xanomeline is an M(1)/M(4) preferring muscarinic receptor agonist which decreased psychotic behaviors in patients with Alzheimer… (More)
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1999
1999
Previous findings in our laboratory suggested that the M1 muscarinic acetylcholine receptor (mAChR) agonist xanomeline exhibits a… (More)
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1998
1998
We investigated the molecular nature of the interaction between the functionally selective M1 muscarinic acetylcholine receptor… (More)
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1997
1997
The therapeutic effects of selective cholinergic replacement using oral xanomeline, an m1/m4 receptor agonist, were assessed in a… (More)
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Highly Cited
1994
Highly Cited
1994
Xanomeline [3(3-hexyloxy-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1- methylpyridine] has been evaluated as a muscarinic receptor… (More)
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