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withaferin A

Known as: (4 beta,5 beta,6 beta,22R)-5,6-epoxy-4,22,27-trihydroxy-1-oxoergosta- 2,24-dien-26-oic acid, delta-lactone, 5,6-epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dienoic acid delta-lactone 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Withanolides

Papers overview

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Review
2020
Review
2020
BRMS1: a multifunctional signaling molecule in metastasis
Despite high mortality rates, molecular understanding of metastasis remains limited. It can be regulated by both pro- and anti… 
2017
2017
Withaferin A protects against spinal cord injury by inhibiting apoptosis and inflammation in mice
Abstract Context: Withaferin A (WFA) exhibits diverse pharmaceutical applications on human diseases, including rheumatoid… 
2016
2016
Obesity: will withaferin win the war?
A new study shows that withaferin A, a steroidal lactone isolated from Withania somnifera, can exert profound metabolic benefits… 
2014
2014
Accumulation of heme oxygenase-1 (HSP32) in Xenopus laevis A6 kidney epithelial cells treated with sodium arsenite, cadmium chloride or proteasomal inhibitors.
Highly Cited
2013
Highly Cited
2013
Stem Cell Marker Nestin Is Critical for TGF-β1-Mediated Tumor Progression in Pancreatic Cancer
The stem cell marker nestin is an intermediate filament protein that plays an important role in cell integrity, migration, and… 
2010
2010
Enhanced bioproduction of withaferin A from suspension cultures of Withania somnifera.
Callus cultures of Withania somnifera from leaves were established on MS (Murashige and Skoog) media supplemented with Dicamba (2… 
2008
2008
Protective role of withaferin‐A on 7,12‐dimethylbenz(a)anthracene‐induced genotoxicity in bone marrow of Syrian golden hamsters
The present study has investigated the antigenotoxic effect of withaferin‐A, a steroidal lactone obtained from the roots and… 
2008
2008
Enhancement of radiation induced cell death in chicken B lymphocytes by withaferin A.
Withaferin A (WA), a plant withanolide, has shown significant radiosensitizing effect in vitro and in vivo. Inhibition of DNA… 
2008
2008
Simultaneous inhibition of the constitutively activated nuclear factor κB and of the Interleukin-6 pathways is necessary and sufficient to completely overcome apoptosis resistance of human U266…
Elevated Nuclear Factor κB (NF-κB) levels have been reported in multiple myeloma cells derived from patients relapsing after… 
Highly Cited
2000
Highly Cited
2000
Radiosensitization of a mouse melanoma by withaferin A: in vivo studies.
The radiosensitizing effect of a plant withanolide, withaferin A, on the B16F1 mouse melanoma was studied in vivo. Treatment of… 
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