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Ghrelin induces adiposity in rodents
The discovery of the peptide hormone ghrelin, an endogenous ligand for the growth hormone secretagogue (GHS) receptor, yielded the surprising result that the principal site of ghrelin synthesis isExpand
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Obesity is associated with hypothalamic injury in rodents and humans.
Rodent models of obesity induced by consuming high-fat diet (HFD) are characterized by inflammation both in peripheral tissues and in hypothalamic areas critical for energy homeostasis. Here weExpand
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The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis
The gastrointestinal peptide hormone ghrelin stimulates appetite in rodents and humans via hypothalamic actions. We discovered expression of ghrelin in a previously uncharacterized group of neuronsExpand
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Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite.
The gut hormone ghrelin targets the brain to promote food intake and adiposity. The ghrelin receptor growth hormone secretagogue 1 receptor (GHSR) is present in hypothalamic centers controllingExpand
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The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis.
The cannabinoid receptor type 1 (CB1) and its endogenous ligands, the endocannabinoids, are involved in the regulation of food intake. Here we show that the lack of CB1 in mice with a disrupted CB1Expand
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Circulating ghrelin levels are decreased in human obesity.
Ghrelin is a novel endogenous natural ligand for the growth hormone (GH) secretagogue receptor that has recently been isolated from the rat stomach. Ghrelin administration stimulates GH secretion butExpand
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Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin.
Ghrelin is a peptide predominantly produced by the stomach. Ghrelin displays strong GH-releasing activity. This activity is mediated by the activation of the so-called GH secretagogue receptor typeExpand
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Ghrelin controls hippocampal spine synapse density and memory performance
The gut hormone and neuropeptide ghrelin affects energy balance and growth hormone release through hypothalamic action that involves synaptic plasticity in the melanocortin system. Ghrelin binding isExpand
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Sirt1 protects against high-fat diet-induced metabolic damage
The identification of new pharmacological approaches to effectively prevent, treat, and cure the metabolic syndrome is of crucial importance. Excessive exposure to dietary lipids causes inflammatoryExpand
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UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals
This corrects the article DOI: 10.1038/nature07181
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