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- Publications
- Influence
Ghrelin induces adiposity in rodents
The discovery of the peptide hormone ghrelin, an endogenous ligand for the growth hormone secretagogue (GHS) receptor, yielded the surprising result that the principal site of ghrelin synthesis is… Expand
Obesity is associated with hypothalamic injury in rodents and humans.
- J. Thaler, C. Yi, +16 authors M. Schwartz
- Medicine
- The Journal of clinical investigation
- 3 January 2012
Rodent models of obesity induced by consuming high-fat diet (HFD) are characterized by inflammation both in peripheral tissues and in hypothalamic areas critical for energy homeostasis. Here we… Expand
The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis
- M. Cowley, R. Smith, +18 authors T. Horvath
- Chemistry, Medicine
- Neuron
- 20 February 2003
The gastrointestinal peptide hormone ghrelin stimulates appetite in rodents and humans via hypothalamic actions. We discovered expression of ghrelin in a previously uncharacterized group of neurons… Expand
Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite.
- A. Abizaid, Z. Liu, +9 authors T. Horvath
- Biology, Medicine
- The Journal of clinical investigation
- 1 December 2006
The gut hormone ghrelin targets the brain to promote food intake and adiposity. The ghrelin receptor growth hormone secretagogue 1 receptor (GHSR) is present in hypothalamic centers controlling… Expand
The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis.
- D. Cota, G. Marsicano, +15 authors U. Pagotto
- Biology, Medicine
- The Journal of clinical investigation
- 1 August 2003
The cannabinoid receptor type 1 (CB1) and its endogenous ligands, the endocannabinoids, are involved in the regulation of food intake. Here we show that the lack of CB1 in mice with a disrupted CB1… Expand
Circulating ghrelin levels are decreased in human obesity.
- M. Tschöp, C. Weyer, P. A. Tataranni, V. Devanarayan, E. Ravussin, M. Heiman
- Medicine
- Diabetes
- 1 April 2001
Ghrelin is a novel endogenous natural ligand for the growth hormone (GH) secretagogue receptor that has recently been isolated from the rat stomach. Ghrelin administration stimulates GH secretion but… Expand
Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin.
- A. J. van der Lely, M. Tschöp, M. Heiman, E. Ghigo
- Biology, Medicine
- Endocrine reviews
- 1 June 2004
Ghrelin is a peptide predominantly produced by the stomach. Ghrelin displays strong GH-releasing activity. This activity is mediated by the activation of the so-called GH secretagogue receptor type… Expand
Ghrelin controls hippocampal spine synapse density and memory performance
- S. Diano, S. Farr, +15 authors T. Horvath
- Biology, Medicine
- Nature Neuroscience
- 1 March 2006
The gut hormone and neuropeptide ghrelin affects energy balance and growth hormone release through hypothalamic action that involves synaptic plasticity in the melanocortin system. Ghrelin binding is… Expand
Sirt1 protects against high-fat diet-induced metabolic damage
- P. Pfluger, D. Herranz, S. Velasco-Miguel, M. Serrano, M. Tschöp
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 15 July 2008
The identification of new pharmacological approaches to effectively prevent, treat, and cure the metabolic syndrome is of crucial importance. Excessive exposure to dietary lipids causes inflammatory… Expand
UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals
- Z. Andrews, Z. Liu, +11 authors S. Diano
- Chemistry
- Nature
- 4 June 2009
This corrects the article DOI: 10.1038/nature07181
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