vismodegib

Known as: Vismodegibum 
An orally bioavailable small molecule with potential antineoplastic activity. Hedgehog antagonist GDC-0449 targets the Hedgehog signaling pathway… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
In the primary analysis of the ERIVANCE BCC trial, vismodegib, the first US Food and Drug Administration–approved Hedgehog… (More)
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Highly Cited
2015
Highly Cited
2015
PURPOSE Sonic hedgehog (SHH), an activating ligand of smoothened (SMO), is overexpressed in > 70% of pancreatic cancers (PCs). We… (More)
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2015
2015
BACKGROUND The Hedgehog pathway inhibitor vismodegib has shown clinical benefit in patients with advanced basal cell carcinoma… (More)
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Highly Cited
2013
Highly Cited
2013
BACKGROUND Vismodegib, a first-in-class Hedgehog pathway inhibitor, was US Food and Drug Administration (FDA) approved for… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND Alterations in hedgehog signaling are implicated in the pathogenesis of basal-cell carcinoma. Although most basal-cell… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND Dysregulated hedgehog signaling is the pivotal molecular abnormality underlying basal-cell carcinomas. Vismodegib is a… (More)
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2012
2012
  • Chris Fellner
  • P & T : a peer-reviewed journal for formulary…
  • 2012
Vismodegib (Erivedge) for advanced basal cell carcinoma. 
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Highly Cited
2011
Highly Cited
2011
PURPOSE The hedgehog (Hh) signaling pathway, a key regulator of cell growth and differentiation during development is implicated… (More)
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Highly Cited
2011
Highly Cited
2011
BACKGROUND Recent evidence from in vitro and in vivo studies has demonstrated that aberrant reactivation of the Sonic Hedgehog… (More)
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2011
2011
PURPOSE Vismodegib (GDC-0449) is a potent and selective inhibitor of the Hedgehog (Hh) pathway that shows antitumor activity in… (More)
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