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GDC-0449

Known as: Hedgehog Antagonist GDC-0449, 2-chloro-N-[4-chloro-3-(pyridin-2-yl)phenyl]-4-(methylsulfonyl)benzamide, GDC 0449 
 
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
Aberrant Hedgehog (Hh)/glioma-associated oncogene (GLI) signaling has been implicated in cancer progression. Here, we analyzed… Expand
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Highly Cited
2014
Highly Cited
2014
Purpose: The hedgehog (HH) signaling pathway is a key regulator in tumorigenesis of pancreatic adenocarcinoma and is upregulated… Expand
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Highly Cited
2012
Highly Cited
2012
BACKGROUND Alterations in hedgehog signaling are implicated in the pathogenesis of basal-cell carcinoma. Although most basal-cell… Expand
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Highly Cited
2011
Highly Cited
2011
Purpose: The hedgehog (Hh) signaling pathway, a key regulator of cell growth and differentiation during development is implicated… Expand
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Highly Cited
2011
Highly Cited
2011
Inappropriate Hedgehog (Hh) signaling has been directly linked to medulloblastoma (MB), a common malignant brain tumor in… Expand
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Highly Cited
2011
Highly Cited
2011
Background Recent evidence from in vitro and in vivo studies has demonstrated that aberrant reactivation of the Sonic Hedgehog… Expand
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Highly Cited
2009
Highly Cited
2009
Medulloblastoma is the most common malignant brain tumor in children. Aberrant activation of the hedgehog signaling pathway is… Expand
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Highly Cited
2009
Highly Cited
2009
SAR for a wide variety of heterocyclic replacements for a benzimidazole led to the discovery of functionalized 2-pyridyl amides… Expand
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Highly Cited
2009
Highly Cited
2009
A Smooth(ened) Path to Drug Resistance The Hedgehog (Hh) signaling pathway has emerged as a key contributor to the growth of… Expand
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Mutations in hedgehog pathway genes, primarily genes encoding patched homologue 1 (PTCH1) and smoothened homologue… Expand
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