GDC-0449

Known as: Hedgehog Antagonist GDC-0449, 2-chloro-N-[4-chloro-3-(pyridin-2-yl)phenyl]-4-(methylsulfonyl)benzamide, GDC 0449 
 
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
PURPOSE The hedgehog (HH) signaling pathway is a key regulator in tumorigenesis of pancreatic adenocarcinoma and is upregulated… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND Alterations in hedgehog signaling are implicated in the pathogenesis of basal-cell carcinoma. Although most basal-cell… (More)
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Highly Cited
2011
Highly Cited
2011
Inappropriate Hedgehog (Hh) signaling has been directly linked to medulloblastoma (MB), a common malignant brain tumor in… (More)
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Highly Cited
2011
Highly Cited
2011
BACKGROUND Recent evidence from in vitro and in vivo studies has demonstrated that aberrant reactivation of the Sonic Hedgehog… (More)
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Highly Cited
2011
Highly Cited
2011
PURPOSE The hedgehog (Hh) signaling pathway, a key regulator of cell growth and differentiation during development is implicated… (More)
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Highly Cited
2011
Highly Cited
2011
PURPOSE In a phase I trial for patients with refractory solid tumors, hedgehog pathway inhibitor vismodegib (GDC-0449) showed… (More)
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Highly Cited
2009
Highly Cited
2009
Medulloblastoma is the most common malignant brain tumor in children. Aberrant activation of the hedgehog signaling pathway is… (More)
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Highly Cited
2009
Highly Cited
2009
SAR for a wide variety of heterocyclic replacements for a benzimidazole led to the discovery of functionalized 2-pyridyl amides… (More)
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Highly Cited
2009
Highly Cited
2009
The Hedgehog (Hh) signaling pathway is inappropriately activated in certain human cancers, including medulloblastoma, an… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Mutations in hedgehog pathway genes, primarily genes encoding patched homologue 1 (PTCH1) and smoothened homologue… (More)
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