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vinorelbine

Known as: Vinorelbin, Dihydroxydeoxynorvinkaleukoblastine, C'-Norvincaleukoblastine, 3',4'-didehydro-4'-deoxy- 
A semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents formation of the mitotic spindle, resulting in the arrest of tumor cell… 
National Institutes of Health

Related topics

Related topics

23 relations

Broader (3)

Antineoplastic Agents, PhytogenicVinblastineanhydrovinblastine
Drug AllergyHodgkin DiseaseMammary NeoplasmsMicrotubule Process

Narrower (3)

KW 2307NavelbineVinorelbine tartrate

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Dose-Ranging Study of Metronomic Oral Vinorelbine in Patients with Advanced Refractory Cancer
Aim: To determine the safe dose range and pharmacokinetics of metronomic oral vinorelbine and obtain preliminary data on… 
Review
2009
Review
2009
Anthracycline- and/or taxane-resistant breast cancer: results of a literature review to determine the clinical challenges and current treatment trends.
Highly Cited
2006
Highly Cited
2006
Impact of cautery versus cautery-free preservation of neurovascular bundles on early return of potency.
PURPOSE To update our short-term potency outcomes from a cautery-free (CFT) versus bipolar cautery technique to preserve the… 
Highly Cited
2006
Highly Cited
2006
Effect of chemotherapy for advanced non-small cell lung cancer on patients' quality of life. A randomized controlled trial.
Highly Cited
2005
Highly Cited
2005
Lateral pedicle control during laparoscopic radical prostatectomy: refined technique.
Highly Cited
2005
Highly Cited
2005
Antivascular Therapy for Orthotopic Human Ovarian Carcinoma through Blockade of the Vascular Endothelial Growth Factor and Epidermal Growth Factor Receptors
Purpose: We determined whether the administration of the tyrosine kinase inhibitor, AEE788, which targets the epidermal growth… 
Highly Cited
2002
Highly Cited
2002
Phase II trial of weekly vinorelbine and trastuzumab as first-line therapy in patients with HER2(+) metastatic breast cancer.
PURPOSE Human epidermal growth factor receptor 2 (HER2) overexpression is associated with a more aggressive form of breast cancer… 
Review
1997
Review
1997
Clinical and pathological response to primary chemotherapy in operable breast cancer.
Highly Cited
1994
Highly Cited
1994
Vinorelbine as first-line chemotherapy for metastatic breast carcinoma.
PURPOSE A phase II trial was performed to evaluate the efficacy and toxicity of vinorelbine (VNB) as first-line chemotherapy for… 
Highly Cited
1985
Highly Cited
1985
Phase I pharmacologic study of a new Vinca alkaloid: navelbine.
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