Vinblastine

Known as: VBL, Vinblastin, VLB 
A natural alkaloid isolated from the plant Vinca rosea Linn. Vinblastine binds to tubulin and inhibits microtubule formation, resulting in disruption… (More)
National Institutes of Health

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Highly Cited
2005
Highly Cited
2005
PURPOSE To compare long-term survival in patients with locally advanced or metastatic transitional cell carcinoma (TCC) of the… (More)
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Highly Cited
2005
Highly Cited
2005
Vinblastine is one of several tubulin-targeting Vinca alkaloids that have been responsible for many chemotherapeutic successes… (More)
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Highly Cited
2000
Highly Cited
2000
Various conventional chemotherapeutic drugs can block angiogenesis or even kill activated, dividing endothelial cells. Such… (More)
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Highly Cited
2000
Highly Cited
2000
PURPOSE Gemcitabine plus cisplatin (GC) and methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) were compared in… (More)
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Highly Cited
1999
Highly Cited
1999
The effects of vinblastine (VBL) on endothelial cell functions involved in angiogenesis, namely proliferation, chemotaxis… (More)
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Highly Cited
1992
Highly Cited
1992
Inhibition of mitosis by many drugs that bind to tubulin has been attributed to depolymerization of microtubules. However, we… (More)
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Highly Cited
1987
Highly Cited
1987
Intrinsic and acquired multidrug resistance (MDR) is an important problem in cancer therapy. MDR in human KB carcinoma cells… (More)
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Highly Cited
1987
Highly Cited
1987
Standard chemotherapy for disseminated germ-cell tumors includes a combination of cisplatin, vinblastine, and bleomycin, but this… (More)
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Highly Cited
1981
Highly Cited
1981
A noncytotoxic dose of verapamil, a coronary vasodilator, enhances the cytotoxicity of vincristine (VCR) and vinblastine in P388… (More)
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Highly Cited
1977
Highly Cited
1977
Fifty patients with disseminated testicular cancer were treated with a three-drug combination consisting of cis… (More)
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