vinflunine

Known as: 4'-Deoxy-20',20'-difluoro-C'-norvincaleukoblastine 
A bi-fluorinated derivative of the semi-synthetic vinca alkaloid vinorelbine with antitubulin, antineoplastic, and antiangiogenic activities… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1998-2018
0102019982018

Papers overview

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Highly Cited
2009
Highly Cited
2009
PURPOSE Vinflunine (VFL) is a new microtubule inhibitor that has activity against transitional cell carcinoma of urothelial tract… (More)
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2006
2006
Angiogenesis is a key event in tumor progression and metastasis. This complex process, which constitutes a potent target for… (More)
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2003
2003
Vinflunine is a novel fluorinated Vinca alkaloid currently in Phase II clinical trials, which in preclinical studies exhibited… (More)
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Highly Cited
2002
Highly Cited
2002
PURPOSE To develop a semimechanistic pharmacokinetic-pharmacodynamic model describing chemotherapy-induced myelosuppression… (More)
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2001
2001
The two second-generation Vinca alkaloids, vinorelbine and vinflunine, affect microtubule dynamics very differently from… (More)
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2000
2000
Vinflunine is a novel Vinca alkaloid presently in Phase I clinical trials. In preclinical studies, it exhibited superior… (More)
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1999
1999
The antitumour activity of vinflunine, 20',20'-dichloro-3',4'-dihydrovinorelbine, a fluorinated Vinca alkaloid obtained by… (More)
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1998
1998
This study aimed to define the mechanism of action of vinflunine, a novel Vinca alkaloid synthesised from vinorelbine using… (More)
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1998
1998
Vinflunine, or 20′,20′-difluoro-3′,4′-dihydrovino‐relbine, is a novel Vinca alkaloid obtained by hemisynthesis using superacidic… (More)
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1998
1998
We present a comparison of the energetics of spiral formation for two vinca alkaloids: a novel difluorinated vinorelbine… (More)
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