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Tubulin Is an Inherent Component of Mitochondrial Membranes That Interacts with the Voltage-dependent Anion Channel*
It is shown by immunoprecipitation experiments that the mitochondrial tubulin is specifically associated with the voltage-dependent anion channel, the main component of the permeability transition pore, and it could play a role in apoptosis via interaction with the permeable Transition pore.
Safety and efficacy of temozolomide in patients with recurrent anaplastic oligodendrogliomas after standard radiotherapy and chemotherapy.
Temozolomide is safe and effective in the treatment of recurrent anaplastic oligodendroglioma and AOA and correlated with improved survival.
Hyperphosphorylation of tau is mediated by ERK activation during anticancer drug‐induced apoptosis in neuroblastoma cells
- S. Guise, D. Braguer, G. Carles, A. Delacourte, C. Briand
- Biology, ChemistryJournal of neuroscience research
- 1 February 2001
The results suggest that tau phosphorylation plays a significant role in apoptosis enhancing disruption of microtubules that in turn leads to formation of apoptotic bodies, suggesting that neurodegeneration and apoptosis are related.
The Glutamine-rich Region of the HIV-1 Tat Protein Is Involved in T-cell Apoptosis*
It is shown that Tat Ug05RP is more efficient than Tat Ug11LTS in its trans-activational role and in inducing apoptosis in binding tubulin via the mitochondrial pathway and the glutamine-rich region of Tat appears to be involved in the Tat-mediated apoptosis of T-cells.
Understanding microtubule dynamics for improved cancer therapy
Identification of proteins regulating the MT network will lead to a better understanding of tumor progression regulators and will be helpful in improving cancer therapy.
Correlation between O6-methylguanine-DNA methyltransferase and survival in inoperable newly diagnosed glioblastoma patients treated with neoadjuvant temozolomide.
- O. Chinot, M. Barrié, D. Figarella-Branger
- Medicine, BiologyJournal of clinical oncology : official journal…
- 20 April 2007
This dose-dense temozolomide regimen resulted in modest antitumor activity with an acceptable safety profile in the neoadjuvant setting, and expression of MGMT correlated with response to temozalomide.
Resistance to Taxol in lung cancer cells associated with increased microtubule dynamics
- A. Gonçalves, D. Braguer, M. Jordan
- BiologyProceedings of the National Academy of Sciences…
- 18 September 2001
The results indicate that microtubule dynamics play an important role in Taxol resistance, and that both excessively rapid dynamics and suppressed dynamics impair mitotic spindle function and inhibit proliferation.
Memo–RhoA–mDia1 signaling controls microtubules, the actin network, and adhesion site formation in migrating cells
- Kossay Zaoui, S. Honoré, D. Isnardon, D. Braguer, A. Badache
- BiologyThe Journal of cell biology
- 3 November 2008
It is reported in this study that Memo controls ErbB2-regulated MT dynamics by altering the transition frequency between MT growth and shortening phases and thatmemo-RhoA-mDia1 signaling coordinates the organization of the lamellipodial actin network, adhesion site formation, and MT outgrowth within the cell leading edge to sustain cell motility.
Phase II study of temozolomide without radiotherapy in newly diagnosed glioblastoma multiforme in an elderly populations
This open‐label, single‐center, Phase II study was designed to evaluate the efficacy and safety of temozolomide as first‐line chemotherapy and exclusive treatment in elderly patients with newly diagnosed GBM.
Paclitaxel induces release of cytochrome c from mitochondria isolated from human neuroblastoma cells'.
It is shown for the first time that paclitaxel acts directly or mitochondria isolated from human cancer cells, and can directly affect mito chondria to induce apoptosis.