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urate oxidase activity

Known as: urate:oxygen oxidoreductase activity, uric acid oxidase activity, uricase activity 
Catalysis of the reaction: urate + O2 + H2O = 5-hydroxyisourate + hydrogen peroxide. [EC:1.7.3.3]
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
Uric acid transporter ABCG2 is increased in the intestine of the 5/6 nephrectomy rat model of chronic kidney disease
BackgroundUric acid (UA) remains a risk factor of chronic kidney disease (CKD). Therefore, it is important to clarify the… 
Highly Cited
2004
Highly Cited
2004
HucR, a Novel Uric Acid-responsive Member of the MarR Family of Transcriptional Regulators from Deinococcus radiodurans*
The MarR family of transcriptional regulators comprises a subset of winged helix DNA-binding proteins and includes numerous… 
Highly Cited
1996
Highly Cited
1996
Nitrogen recycling in the brown planthopper, Nilaparvata lugens: Involvement of yeast-like endosymbionts in uric acid metabolism
Highly Cited
1995
Highly Cited
1995
Effect of chronic experimental renal insufficiency on urate metabolism.
The rise in plasma uric acid (UA) in chronic renal failure (CRF) is quite limited. This may be due to either increased extrarenal… 
Highly Cited
1983
Highly Cited
1983
Nodulin‐35: a subunit of specific uricase (uricase II) induced and localized in the uninfected cells of soybean nodules
Nodulin‐35, a protein specific to soybean root nodules, was purified under non‐denaturing conditions (DEAE‐cellulose followed by… 
Highly Cited
1973
Highly Cited
1973
LOCALIZATION OF ENZYMES WITHIN MICROBODIES
Microbodies from rat liver and a variety of plant tissues were osmotically shocked and subsequently centrifuged at 40,000 g for… 
Highly Cited
1970
Highly Cited
1970
Urate oxidase in primate phylogenesis.
1 Several genera of New World monkeys have high uric acid concentrations in serum and urine comparable to man and the higher… 
Highly Cited
1966
Highly Cited
1966
Comparative ultrastructure of hepatic microbodies in some mammals and birds in relation to species differences in uricase activity.
Highly Cited
1965
Highly Cited
1965
THE HISTOCHEMICAL DEMONSTRATION OF URICASE ACTIVITY
The histochemical demonstration of uricase activity in rat and guinea pig liver is described. The technique depends upon the… 
Highly Cited
1956
Highly Cited
1956
CENTRIFUGAL, BIOCHEMICAL, AND ELECTRON MICROSCOPIC ANALYSIS OF CYTOPLASMIC PARTICULATES IN LIVER HOMOGENATES
A combined centrifugal, biochemical, and electron microscopic study of the cytoplasmic particulates present in 0.88 M sucrose… 
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