urate oxidase activity

Known as: urate:oxygen oxidoreductase activity, uric acid oxidase activity, uricase activity 
Catalysis of the reaction: urate + O2 + H2O = 5-hydroxyisourate + hydrogen peroxide. [EC:1.7.3.3]
National Institutes of Health

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Highly Cited
2008
Highly Cited
2008
Uric acid is the end product of purine metabolism in humans and great apes, which have lost hepatic uricase activity, leading to… (More)
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Highly Cited
2008
Highly Cited
2008
OBJECTIVE To assess the efficacy of pegloticase in achieving and maintaining plasma urate levels of <6 mg/dl in gout patients in… (More)
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Highly Cited
2007
Highly Cited
2007
OBJECTIVE To evaluate the efficacy, immunogenicity, and tolerability of intravenous (IV) PEGylated recombinant mammalian urate… (More)
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Highly Cited
2005
Highly Cited
2005
PEG-modified recombinant mammalian urate oxidase (PEG-uricase) is being developed as a treatment for patients with chronic gout… (More)
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2003
2003
Planthopper harbour yeast-like symbionts in the mycetocyte. A possible role that the symbionts may play for the host insect is… (More)
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1995
1995
The rise in plasma uric acid (UA) in chronic renal failure (CRF) is quite limited. This may be due to either increased extrarenal… (More)
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Highly Cited
1992
Highly Cited
1992
Urate oxidase was lost in hominoids during primate evolution. The mechanism and biological reason for this loss remain unknown… (More)
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1976
1976
The behavior of the rate-limiting enzyme of purine catabolism, xanthine oxidase (EC 1.2.3.2); was examined in normal liver, in 17… (More)
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1973
1973
Microbodies from rat liver and a variety of plant tissues were osmotically shocked and subsequently centrifuged at 40,000 g for… (More)
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