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urate oxidase activity

Known as: urate:oxygen oxidoreductase activity, uric acid oxidase activity, uricase activity 
Catalysis of the reaction: urate + O2 + H2O = 5-hydroxyisourate + hydrogen peroxide. [EC:1.7.3.3]
National Institutes of Health

Papers overview

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Review
2010
Review
2010
Uric acid (UA) is the end product of purine metabolism in humans due to the loss of uricase activity by various mutations of its… Expand
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Highly Cited
2008
Highly Cited
2008
Uric acid is the end product of purine metabolism in humans and great apes, which have lost hepatic uricase activity, leading to… Expand
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Highly Cited
2007
Highly Cited
2007
OBJECTIVE To evaluate the efficacy, immunogenicity, and tolerability of intravenous (IV) PEGylated recombinant mammalian urate… Expand
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Highly Cited
2006
Highly Cited
2006
PEG-modified recombinant mammalian urate oxidase (PEG-uricase) is being developed as a treatment for patients with chronic gout… Expand
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Highly Cited
2004
Highly Cited
2004
SummaryUrate oxidase was lost in hominoids during primate evolution. The mechanism and biological reason for this loss remain… Expand
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Highly Cited
2004
Highly Cited
2004
The MarR family of transcriptional regulators comprises a subset of winged helix DNA-binding proteins and includes numerous… Expand
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Highly Cited
1996
Highly Cited
1996
Abstract Planthopper harbour yeast-like symbionts in the mycetocyte. A possible role that the symbionts may play for the host… Expand
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Highly Cited
1983
Highly Cited
1983
Nodulin‐35, a protein specific to soybean root nodules, was purified under non‐denaturing conditions (DEAE‐cellulose followed by… Expand
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Highly Cited
1973
Highly Cited
1973
Microbodies from rat liver and a variety of plant tissues were osmotically shocked and subsequently centrifuged at 40,000 g for… Expand
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Highly Cited
1957
Highly Cited
1957
1. A transplantable tumor was established in 1951 from a primary nodule and mesenteric metastases of a DAB-induced liver tumor… Expand
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