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uracil glycol

Known as: 5,6-dihydroxy-5,6-dihydrouracil, Ug cpd 
National Institutes of Health

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Broader (1)

Uracil
analogs & derivatives

Papers overview

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2012
2012
Profiling cytosine oxidation in DNA by LC-MS/MS.
Spontaneous and oxidant-induced damage to cytosine is probably the main cause of CG to TA transition mutations in mammalian… 
2000
2000
Spontaneous and osmium tetroxide-induced mutagenesis in an Escherichia coli strain deficient in both endonuclease III and endonuclease VIII.
Thymine glycol, uracil glycol, 5-hydroxycytosine and 5-hydroxyuracil are common base lesions produced by cellular metabolism as… 
Highly Cited
1999
Highly Cited
1999
Saccharomyces cerevisiae Ntg1p and Ntg2p: broad specificity N-glycosylases for the repair of oxidative DNA damage in the nucleus and mitochondria.
Saccharomyces cerevisiae possesses two functional homologues (Ntg1p and Ntg2p) of the Escherichia coli endonuclease III protein… 
Highly Cited
1998
Highly Cited
1998
Enzymatic Processing of Uracil Glycol, a Major Oxidative Product of DNA Cytosine*
A major stable oxidation product of DNA cytosine is uracil glycol (Ug). Because of the potential of Ug to be a strong… 
1997
1997
Kinetics of oxidized cytosine repair by endonuclease III of Escherichia coli.
Endonuclease III of Escherichia coli excises a broad range of oxidized, hydrated and ring-fragmented pyrimidines from DNA. The… 
Highly Cited
1995
Highly Cited
1995
Oxidative damage to 5-methylcytosine in DNA.
Exposure of pyrimidines of DNA to ionizing radiation under aerobic conditions or oxidizing agents results in attack on the 5,6… 
Highly Cited
1994
Highly Cited
1994
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of chemically modified oligonucleotides.
A variety of chemically modified oligonucleotides have been studied by matrix-assisted laser desorption/ionization time-of-flight… 
1987
1987
Radiation chemistry of 2'-deoxycytidylyl-(3'-5')-2'-deoxyguanosine and its sequence isomer in N2O- and O2-saturated solutions.
The radiation chemistry of the dinucleoside monophosphate d(CpG) and its sequence isomer, d(GpC), has been examined in aqueous… 
Highly Cited
1986
Highly Cited
1986
Formation of cytosine glycol and 5,6-dihydroxycytosine in deoxyribonucleic acid on treatment with osmium tetroxide.
OsO4 selectively forms thymine glycol lesions in DNA. In the past, OsO4-treated DNA has been used as a substrate in studies of… 
1983
1983
Effect of iron (III) ions on the radiosensitivity of uracil.
Aqueous solutions of uracil(U) in the presence of iron(III) were irradiated with 60Co gamma-rays both in the presence and in the… 
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