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Spontaneous and oxidant-induced damage to cytosine is probably the main cause of CG to TA transition mutations in mammalian… Expand The principal oxidized cytosine bases, uracil glycol, 5-hydroxycytosine, and 5-hydroxyuracil, are readily bypassed, miscode, and… Expand Saccharomyces cerevisiae possesses two functional homologues (Ntg1p and Ntg2p) of the Escherichia coli endonuclease III protein… Expand A major stable oxidation product of DNA cytosine is uracil glycol (Ug). Because of the potential of Ug to be a strong… Expand The most common base substitution arising from oxidative damage of DNA is a GC --> AT transition. In an effort to determine the… Expand Exposure of pyrimidines of DNA to ionizing radiation under aerobic conditions or oxidizing agents results in attack on the 5,6… Expand A variety of chemically modified oligonucleotides have been studied by matrix-assisted laser desorption/ionization time-of-flight… Expand The excision of modified bases from DNA by Escherichia coli endonuclease III was investigated. Modified bases were produced in… Expand The radiation chemistry of the dinucleoside monophosphate d(CpG) and its sequence isomer, d(GpC), has been examined in aqueous… Expand OsO4 selectively forms thymine glycol lesions in DNA. In the past, OsO4-treated DNA has been used as a substrate in studies of… Expand