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ubiquitinyl hydrolase activity

Known as: ubiquitin C-terminal hydrolase, ubiquitin hydrolase activity, thiol-dependent ubiquitinyl hydrolase activity 
Catalysis of the thiol-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin… 
National Institutes of Health

Related topics

Related topics

3 relations
thiol-dependent ubiquitin-specific protease activity

Narrower (2)

ubiquitin-specific protease activity involved in negative regulation of ERAD pathwayubiquitin-specific protease activity involved in positive regulation of ERAD pathway

Papers overview

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2020
2020
USP9X prevents AGEs-induced upregulation of FN and TGF-β1 through activating Nrf2-ARE pathway in rat glomerular mesangial cells.
2018
2018
OTUB1 protein suppresses mTOR complex 1 (mTORC1) activity by deubiquitinating the mTORC1 inhibitor DEPTOR
Mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) integrates various environmental signals to regulate cell growth and… 
2018
2018
The deubiquitinase ubiquitin–specific protease 20 is a positive modulator of myocardial β1-adrenergic receptor expression and signaling
Reversible ubiquitination of G protein–coupled receptors regulates their trafficking and signaling; whether deubiquitinases… 
2017
2017
Ubiquitin-specific peptidase 48 regulates Mdm2 protein levels independent of its deubiquitinase activity
The overexpression of Mdm2 has been linked to the loss of p53 tumour suppressor activity in several human cancers. Here, we… 
Highly Cited
2014
Highly Cited
2014
The deubiquitinase activity of A20 is dispensable for NF‐κB signaling
A20 has been suggested to limit NF‐κB activation by removing regulatory ubiquitin chains from ubiquitinated substrates. A20 is a… 
2014
2014
IKK regulates the deubiquitinase CYLD at the postsynaptic density.
2014
2014
Mode of substrate recognition by the Josephin domain of ataxin‐3, which has an endo‐type deubiquitinase activity
2013
2013
Excitotoxic stimulation downregulates the ubiquitin-proteasome system through activation of NMDA receptors in cultured hippocampal neurons.
2011
2011
The Deubiquitinase Activity of the Salmonella Pathogenicity Island 2 Effector, SseL, Prevents Accumulation of Cellular Lipid Droplets
ABSTRACT To cause disease, Salmonella enterica serovar Typhimurium requires two type III secretion systems that are encoded by… 
Highly Cited
2010
Highly Cited
2010
The A20 Deubiquitinase Activity Negatively Regulates LMP1 Activation of IRF7
ABSTRACT A20 possesses both deubiquitinase (DUB) and ubiquitin E3 ligase activities that are required for termination of Toll… 
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