ubiquilin
National Institutes of Health
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Amyotrophic lateral sclerosis (ALS) is a degenerative disorder that is characterized by loss of motor neurons and shows clinical…
BackgroundUbiquilins are proteins that function as ubiquitin receptors in eukaryotes. Mutations in two ubiquilin-encoding genes…
Background: Ubiquilin-1 may contribute to the development of Alzheimer disease; however, the mechanisms are unclear. Results…
BackgroundAlzheimer's disease (AD) is common and highly heritable with many genes and gene variants associated with AD in one or…
Eps15 and its related protein Eps15R are key components of the clathrin-mediated endocytic pathway. We searched for new binding…
Mutations in presenilin proteins (PS1 and PS2) are associated with most cases of early-onset Alzheimer's disease. Several…
Up-regulation of several stress proteins such as heat-shock proteins and glucose-regulated proteins participate in tolerance…
Mutations in the highly homologous presenilin genes encoding presenilin-1 and presenilin-2 (PS1 and PS2) are linked to early…